3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

被引:83
作者
Yu, Xiaoling [1 ]
Zhang, Tian [1 ,2 ]
Li, Yuan [1 ]
机构
[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China
[2] Wuhan Univ Technol, State Key Lab Silicate Mat Architectures, Wuhan 430070, Peoples R China
关键词
3D printing; bioprinting; hydrogel; polyester; peripheral nerve regeneration; CONDUCTIVE POLYMERS; STEM-CELLS; ELECTRICAL-STIMULATION; POLYURETHANE HYDROGEL; FUNCTIONAL RECOVERY; COMPOSITE HYDROGEL; GUIDANCE CONDUITS; REGENERATION; SCAFFOLDS; DIFFERENTIATION;
D O I
10.3390/polym12081637
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Fabrication of nerve conduits for perfectly repairing or replacing damaged peripheral nerve is an urgent demand worldwide, but it is also a formidable clinical challenge. In the last decade, with the rapid development of manufacture technologies, 3D printing and bioprinting have been becoming remarkable stars in the field of neural engineering. In this review, we explore that the biomaterial inks (hydrogels, thermoplastic, and thermoset polyesters and composite) and bioinks have been selected for 3D printing and bioprinting of peripheral nerve conduits. This review covers 3D manufacturing technologies, including extrusion printing, inkjet printing, stereolithography, and bioprinting with inclusion of cells, bioactive molecules, and drugs. Finally, an outlook on the future directions of 3D printing and 4D printing in customizable nerve therapies is presented.
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页数:27
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