Enantioselective Aluminum-Free Alkene Hydroarylations through C-H Activation by a Chiral Nickel/JoSPOphos Manifold

被引：70
作者：
Loup, Joachim [1 ]
Mueller, Valentin [1 ]
Ghorai, Debasish [1 ,2 ]
Ackermann, Lutz [1 ,2 ]
机构：
[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
[2] Univ Pavia, Dept Chem, Viale Taramelli 10, I-27100 Pavia, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 06期
关键词：
aluminum-free; asymmetric catalysis; C-H activation; nickel; SPOs; BOND ACTIVATION; SELECTIVE ALKENYLATION; PHOSPHINE OXIDES; METAL; FUNCTIONALIZATION; ALKYNES; ALKYLATION; MECHANISM; HYDROHETEROARYLATION; HETEROCYCLES;
D O I：
10.1002/anie.201813191
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly enantioselective nickel-catalyzed alkene endo-hydroarylations were accomplished with full selectivity by organometallic C-H activation. The asymmetric assembly of chiral six-membered scaffolds proved viable in the absence of pyrophoric organoaluminum reagents within an unprecedented nickel/JoSPOphos manifold.
引用
收藏
页码：1749 / 1753
页数：5
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