Enantioselective Aluminum-Free Alkene Hydroarylations through C-H Activation by a Chiral Nickel/JoSPOphos Manifold

被引：70

作者：

Loup, Joachim ^{[1
]}

Mueller, Valentin ^{[1
]}

Ghorai, Debasish ^{[1
,2
]}

Ackermann, Lutz ^{[1
,2
]}

机构：

[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

[2] Univ Pavia, Dept Chem, Viale Taramelli 10, I-27100 Pavia, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 06期

关键词：

aluminum-free; asymmetric catalysis; C-H activation; nickel; SPOs; BOND ACTIVATION; SELECTIVE ALKENYLATION; PHOSPHINE OXIDES; METAL; FUNCTIONALIZATION; ALKYNES; ALKYLATION; MECHANISM; HYDROHETEROARYLATION; HETEROCYCLES;

D O I：

10.1002/anie.201813191

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantioselective nickel-catalyzed alkene endo-hydroarylations were accomplished with full selectivity by organometallic C-H activation. The asymmetric assembly of chiral six-membered scaffolds proved viable in the absence of pyrophoric organoaluminum reagents within an unprecedented nickel/JoSPOphos manifold.

引用

页码：1749 / 1753

页数：5

共 101 条

[1] Catalytic arylation reactions by C-H bond activation with aryl tosylates [J].