Class I histone deacetylase inhibition is a novel mechanism to target regulatory T cells in immunotherapy

被引：50

作者：

Shen, Li ^{[1
]}

Pili, Roberto ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 06期

关键词：

HDAC inhibitors; regulatory T cells; Foxp3; immunotherapy; STAT3; FUNCTIONALITY; ACETYLATION;

D O I：

10.4161/onci.20306

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Regulatory T cells (Tregs) represent a major obstacle of cancer immunotherapy. We reviewed here our discovery that Class I histone deacetylase (HDAC) inhibition can functionally target Tregs and help break the immune tolerance. We also discuss the effects of different classes of HDAC inhibitors on Tregs and the underline mechanisms, which may have a direct impact on designing cancer immunotherapy trials involving HDAC inhibitors.

引用

收藏

页码：948 / 950

页数：3

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