Synthesis of the functionalized spiro[indoline-3,5′-pyrroline]-2,2′-diones via three-component reactions of arylamines, acetylenedicarboxylates, and isatins

被引：58

作者：

Han, Ying ^{[1
]}

Wu, Qun ^{[1
]}

Sun, Jing ^{[1
]}

Yan, Chao-Guo ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

TETRAHEDRON | 2012年 / 68卷 / 41期

基金：

中国国家自然科学基金;

关键词：

Multicomponent reaction; Domino reaction; Electron-deficient alkyne; Isatin; Spiro compound; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; MULTICOMPONENT REACTIONS; AROMATIC-ALDEHYDES; DIASTEREOSELECTIVE SYNTHESIS; 4-COMPONENT REACTIONS; AZOMETHINE YLIDES; FACILE SYNTHESIS; CONSTRUCTION; SPIRO;

D O I：

10.1016/j.tet.2012.08.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of p-toluenesulfonic acid as the catalyst the three-component reactions of arylamines, acetylenedicarboxylates, and isatins showed very interesting molecular diversity. When equal amount of arylamine was used, the three-component reaction resulted in the high yields of functionalized 3'-hydroxyspiro[indoline-3,5'-pyrroline]-2,2'-dione derivatives. On the other hand the functionalized 3'-N-arylaminospiro[indoline-3,5'-pyrroline]-2,2'-diones were also successfully prepared in satisfactory yields by using 2 M arylamine in the reaction. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：8539 / 8544

页数：6

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