Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles

被引：368

作者：

Dai, Yunlu ^{[1
,2
]}

Yang, Zhen ^{[2
]}

Cheng, Siyuan ^{[2
]}

Wang, Zhongliang ^{[1
]}

Zhang, Ruili ^{[1
]}

Zhu, Guizhi ^{[2
]}

Wang, Zhantong ^{[2
]}

Yung, Bryant C. ^{[2
]}

Tian, Rui ^{[2
]}

Jacobson, Orit ^{[2
]}

Xu, Can ^{[2
]}

Ni, Qianqian ^{[2
]}

Song, Jibin ^{[2
]}

Sun, Xiaolian ^{[3
,4
]}

Niu, Gang ^{[2
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol Imaging & Neuroimaging, Minist Educ, Xian 710126, Shaanxi, Peoples R China

[2] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA

[3] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China

[4] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging, Xiamen 361005, Peoples R China

来源：

ADVANCED MATERIALS | 2018年 / 30卷 / 08期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

combination therapy; metal-polyphenol networks; positron emission tomography; reactive oxygen species; self-assembly; CANCER-THERAPY; POLY(ETHYLENE GLYCOL); FENTON REACTION; CHEMOTHERAPY; DOXORUBICIN; CISPLATIN; GENERATION; DELIVERY; NANOMATERIALS; SUPEROXIDE;

D O I：

10.1002/adma.201704877

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, a reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via a biocompatible metal-polyphenol networks self-assembly process by encapsulating doxorubicin (DOX) and platinum prodrugs in nanoparticles. Both DOX and platinum drugs can activate nicotinamide adenine dinucleotide phosphate oxidases, generating superoxide radicals (O-2(center dot-)). The superoxide dismutase-like activity of polyphenols can catalyze H2O2 generation from O-2(center dot-). Finally, the highly toxic HO center dot free radicals are generated by a Fenton reaction. The ROS HO center dot can synergize the chemotherapy by a cascade of bioreactions. Positron emission tomography imaging of Zr-89-labeled as-prepared DOX@Pt prodrug Fe3+ nanoparticles (DPPF NPs) shows prolonged blood circulation and high tumor accumulation. Furthermore, the DPPF NPs can effectively inhibit tumor growth and reduce the side effects of anticancer drugs. This study establishes a novel ROS promoted synergistic nanomedicine platform for cancer therapy.

引用

页数：8

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