Thiamin biosynthesis: still yielding fascinating biological chemistry

被引：32
作者：
Begley, Tadhg P. [1 ]
Ealick, Steven E. [2 ]
McLafferty, Fred W. [2 ]
机构：
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA
[2] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷
基金：
美国国家卫生研究院;
关键词：
Bacillus subtilis; Saccharomyces cerevisiae; thiamin biosynthesis; thiamin thiazole; SULFUR CARRIER PROTEIN; ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; MYCOBACTERIUM-TUBERCULOSIS; BACILLUS-SUBTILIS; THIAZOLE MOIETY; SYNTHASE; INTERMEDIATE; COMPLEX; IDENTIFICATION;
D O I：
10.1042/BST20120084
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys(205) of the thiazole synthase.
引用
收藏
页码：555 / 560
页数：6
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