Hippo Signaling Goes Long Range

被引：28
作者：
Codelia, Veronica A.
Irvine, Kenneth D. [1 ]
机构：
[1] Rutgers State Univ, Howard Hughes Med Inst, Waksman Inst, Piscataway, NJ 08854 USA
来源：
CELL | 2012年 / 150卷 / 04期
关键词：
F-ACTIN; PATHWAY; PROTEIN; GROWTH; CANCER;
D O I：
10.1016/j.cell.2012.07.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
引用
收藏
页码：669 / 670
页数：2
相关论文
共 10 条
[1]   MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability [J].
Densham, Ruth M. ;
O'Neill, Eric ;
Munro, June ;
Koenig, Ireen ;
Anderson, Kurt ;
Kolch, Walter ;
Olson, Michael F. .
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (24) :6380-6390
[2]   G-protein-coupled receptors and cancer [J].
Dorsam, Robert T. ;
Gutkind, J. Silvio .
NATURE REVIEWS CANCER, 2007, 7 (02) :79-94
[3]   Role of YAP/TAZ in mechanotransduction [J].
Dupont, Sirio ;
Morsut, Leonardo ;
Aragona, Mariaceleste ;
Enzo, Elena ;
Giulitti, Stefano ;
Cordenonsi, Michelangelo ;
Zanconato, Francesca ;
Le Digabel, Jimmy ;
Forcato, Mattia ;
Bicciato, Silvio ;
Elvassore, Nicola ;
Piccolo, Stefano .
NATURE, 2011, 474 (7350) :179-U212
[4]   Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila [J].
Fernandez, Beatriz Garcia ;
Gaspar, Pedro ;
Bras-Pereira, Catarina ;
Jezowska, Barbara ;
Rebelo, Sofia Raquel ;
Janody, Florence .
DEVELOPMENT, 2011, 138 (11) :2337-2346
[5]   The Hippo Signaling Pathway in Development and Cancer [J].
Pan, Duojia .
DEVELOPMENTAL CELL, 2010, 19 (04) :491-505
[6]   Modulating F-actin organization induces organ growth by affecting the Hippo pathway [J].
Sansores-Garcia, Leticia ;
Bossuyt, Wouter ;
Wada, Ken-Ichi ;
Yonemura, Shigenobu ;
Tao, Chunyao ;
Sasaki, Hiroshi ;
Halder, Georg .
EMBO JOURNAL, 2011, 30 (12) :2325-2335
[7]   Hippo signaling in Drosophila: Recent advances and insights [J].
Staley, Binnaz Kucuk ;
Irvine, Kenneth D. .
DEVELOPMENTAL DYNAMICS, 2012, 241 (01) :3-15
[8]   Hippo pathway regulation by cell morphology and stress fibers [J].
Wada, Ken-Ichi ;
Itoga, Kazuyoshi ;
Okano, Teruo ;
Yonemura, Shigenobu ;
Sasaki, Hiroshi .
DEVELOPMENT, 2011, 138 (18) :3907-3914
[9]   Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling [J].
Yu, Fa-Xing ;
Zhao, Bin ;
Panupinthu, Nattapon ;
Jewell, Jenna L. ;
Lian, Ian ;
Wang, Lloyd H. ;
Zhao, Jiagang ;
Yuan, Haixin ;
Tumaneng, Karen ;
Li, Hairi ;
Fu, Xiang-Dong ;
Mills, Gordon B. ;
Guan, Kun-Liang .
CELL, 2012, 150 (04) :780-791
[10]   Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis [J].
Zhao, Bin ;
Li, Li ;
Wang, Lloyd ;
Wang, Cun-Yu ;
Yu, Jindan ;
Guan, Kun-Liang .
GENES & DEVELOPMENT, 2012, 26 (01) :54-68
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