Hippo Signaling Goes Long Range

被引：28
作者：
Codelia, Veronica A.
Irvine, Kenneth D. [1 ]
机构：
[1] Rutgers State Univ, Howard Hughes Med Inst, Waksman Inst, Piscataway, NJ 08854 USA
来源：
CELL | 2012年 / 150卷 / 04期
关键词：
F-ACTIN; PATHWAY; PROTEIN; GROWTH; CANCER;
D O I：
10.1016/j.cell.2012.07.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
引用
收藏
页码：669 / 670
页数：2
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