Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma

被引：6
作者：
Zhang, Jian [1 ]
Deng, Jianjian [1 ]
Ding, Rui [1 ]
Yuan, Jinghong [1 ]
Liu, Jiahao [1 ]
Zhao, Xiaokun [1 ]
Wu, Tianlong [3 ]
Jia, Jingyu [1 ]
Cheng, Xigao [2 ,3 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Dept Orthoped, Nanchang 330006, Jiangxi, Peoples R China
[2] Inst Orthoped Jiangxi Prov, Nanchang 330006, Jiangxi, Peoples R China
[3] Nanchang Univ, Inst Minimally Invas Orthoped, Nanchang 330006, Jiangxi, Peoples R China
来源：
CANCER CELL INTERNATIONAL | 2022年 / 22卷 / 01期
关键词：
Osteosarcoma; Pyroptosis; lncRNA; Biomarkers; Prognostic signature; GASTRIC-CANCER; CELL-DEATH; GRANZYME-A; GASDERMIN; PORE; ACTIVATION; MECHANISM; RELEASE; GSDMD;
D O I：
10.1186/s12935-022-02729-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteosarcoma is a highly malignant tumor, with very high disability and fatality rates. However, the overall prognosis is not optimistic. Pyroptosis is a newly discovered cell death modality accompanied by inflammation, which is closely related to varieties of cancers. In this study, the RNA-seq data were downloaded from public databases, the differences in the expression of the pyroptosis-related genes (PRGs) were identified, and the six PRGs signature was established through the univariate and LASSO Cox analysis. The patients were grouped according to the PRGs signature, and the prognosis between the two groups was further compared. In addition, a ten pyroptosis-related lncRNAs (PRLs) prognostic signature was also constructed. Through functional analysis of the differentially expressed genes (DEGs), the immune-related pathways were found to be enriched. The Pearson correlation analysis showed a strong correlation between the pyroptosis-related biomarkers. Finally, we identified a promising biomarker, CHMP4C, which is highly expressed in osteosarcoma. Overexpression of CHMP4C promoted the proliferation, migration and invasion of the osteosarcoma cell. Our results thus provide new evidence for exploring prognostic biomarkers and therapeutic targets of osteosarcoma.
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页数：18
相关论文
共 66 条
[61]   Downregulation of the long non-coding RNA FOXD2-AS1 inhibits cell proliferation, migration and invasion in osteosarcoma [J].
Zhang, Haomeng ;
Lu, Yao ;
Wang, Jun ;
Zhang, Tian ;
Dong, Chuan ;
Li, Xiaoxiang ;
Wang, Xinli ;
Ma, Qiong ;
Yang, Tongtao ;
Zhou, Yong .
MOLECULAR MEDICINE REPORTS, 2019, 20 (01) :292-302
[62]   LncRNA FOXD2-AS1 knockdown inhibits the resistance of human osteosarcoma cells to cisplatin by inhibiting miR-143 expression [J].
Zhang, Q-Q ;
Xu, S-L ;
Ding, C. ;
Ma, C-C ;
Yuan, T-S ;
Hua, C-C ;
Wang, X-H .
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2021, 25 (02) :678-686
[63]   A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma [J].
Zhang, Yiming ;
He, Rong ;
Lei, Xuan ;
Mao, Lianghao ;
Jiang, Pan ;
Ni, Chenlie ;
Yin, Zhengyu ;
Zhong, Xinyu ;
Chen, Chen ;
Zheng, Qiping ;
Li, Dapeng .
FRONTIERS IN GENETICS, 2021, 12
[64]   Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense [J].
Zheng, Min ;
Karki, Rajendra ;
Vogel, Peter ;
Kanneganti, Thirumala-Devi .
CELL, 2020, 181 (03) :674-+
[65]   Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells [J].
Zhou, Zhiwei ;
He, Huabin ;
Wang, Kun ;
Shi, Xuyan ;
Wang, Yupeng ;
Su, Ya ;
Wang, Yao ;
Li, Da ;
Liu, Wang ;
Zhang, Yongliang ;
Shen, Lianjun ;
Han, Weidong ;
Shen, Lin ;
Ding, Jingjin ;
Shao, Feng .
SCIENCE, 2020, 368 (6494) :965-+
[66]   Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer [J].
Zhu, Li-Li ;
Wu, Zheng ;
Li, Rong-Kun ;
Xing, Xin ;
Jiang, Yong-Sheng ;
Li, Jun ;
Wang, Ya-Hui ;
Hu, Li-Peng ;
Wang, Xu ;
Qin, Wei-Ting ;
Sun, Yong-Wei ;
Zhang, Zhi-Gang ;
Yang, Qin ;
Jiang, Shu-Heng .
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2021, 17 (01) :107-118
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