The development of RAPTA compounds for the treatment of tumors

被引：403

作者：

Murray, Benjamin S. ^{[1
]}

Babak, Maria V. ^{[2
]}

Hartinger, Christian G. ^{[2
]}

Dyson, Paul J. ^{[3
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand

[3] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

COORDINATION CHEMISTRY REVIEWS | 2016年 / 306卷

关键词：

RAPTA; Bioorganometallic chemistry; Cancer; Metastasis; Angiogenesis; ARENE RUTHENIUM COMPLEXES; METALLODRUG-PROTEIN INTERACTIONS; IN-VITRO; ANTICANCER COMPLEXES; METAL-COMPLEXES; PTA COMPLEXES; BREAST-CANCER; DNA-BINDING; RUTHENIUM(II)-ARENE COMPLEXES; ORGANOMETALLIC RUTHENIUM(II);

D O I：

10.1016/j.ccr.2015.06.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：86 / 114

页数：29

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