Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold

被引：38

作者：

Li, Xiang ^{[1
]}

Yang, Lei ^{[1
]}

Peng, Cheng ^{[1
,2
]}

Xie, Xin ^{[1
]}

Leng, Hai-Jun ^{[2
]}

Wang, Biao ^{[2
]}

Tang, Zheng-Wei ^{[2
]}

He, Gu ^{[3
]}

Ouyang, Liang ^{[3
]}

Huang, Wei ^{[2
]}

Han, Bo ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China

[3] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 77期

基金：

中国博士后科学基金; 美国国家科学基金会;

关键词：

ENANTIOSELECTIVE SYNTHESIS; CONJUGATED NITROALKENES; ANTICANCER ACTIVITY; DIENAMINE CATALYSIS; CASCADE; CONSTRUCTION; STEREOCENTERS; DERIVATIVES; SEQUENCE; ENALS;

D O I：

10.1039/c3cc44004d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel multicatalytic MBH-Michael tandem reaction has been developed for the asymmetric assembly of ninhydrin, nitroolefins and aldehydes into a structurally complex oxa-spirocyclic indanone backbone. Successive iodocyclization allowed us to convert these multifunctional allylic products into fused chiral natural product mimics.

引用

页码：8692 / 8694

页数：3

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