Structural insights into semaphorins and their receptors

被引：51

作者：

Siebold, Christian ^{[1
]}

Jones, E. Yvonne ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Div Struct Biol, Oxford OX3 7BN, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2013年 / 24卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Crystal structure; Molecular mechanism; Cell surface receptor; Protein interactions; GTPASE-ACTIVATING PROTEIN; CRYSTAL-STRUCTURE; BINDING DOMAIN; SEMA DOMAIN; CHEMOREPULSIVE ACTIVITY; SECRETED SEMAPHORINS; AXON GUIDANCE; MET RECEPTOR; R-RAS; PLEXIN;

D O I：

10.1016/j.semcdb.2012.11.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ten years ago nothing was known of the three-dimensional structure of members of the semaphorin family of cell guidance cues, nor of their major receptors, the plexins. The structural biology of this cell surface ligand-receptor system has now come of age. Detailed atomic level information is available on the architecture of semaphorin and plexin ectodomains and their recognition complexes. Similarly the structure of the plexin cytoplasmic region, and its interactions with members of the Rho family of small GTPases have been unveiled. These structural analyses, in combination with biochemical, biophysical and cellular studies, have progressed our understanding of this signalling system into the realm of molecular mechanism. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：139 / 145

页数：7

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