Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway

被引：19
|
作者：
Pang, L. Y. [1 ,2 ]
Blacking, T. M. [1 ,2 ]
Else, R. W. [1 ,2 ]
Sherman, A. [1 ,2 ]
Sang, H. M. [1 ,2 ]
Whitelaw, B. A. [1 ,2 ]
Hupp, T. R. [3 ]
Argyle, D. J. [3 ]
机构：
[1] Univ Edinburgh, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotland
[2] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH25 9RG, Midlothian, Scotland
[3] Univ Edinburgh, Inst Genet & Mol Med, Canc Res UK Cell Signalling Unit, Edinburgh EH4 2XR, Midlothian, Scotland
来源：
VETERINARY JOURNAL | 2013年 / 196卷 / 03期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Feline mammary carcinoma; Cancer stem cell; p53; Epithelial-mesenchymal transition; OCCURRING TUMORS; CULTURE-SYSTEM; IDENTIFICATION; GROWTH;
D O I：
10.1016/j.tvjl.2012.10.021
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in the NOD-SCID mouse and chick embryo models. This population of feline mammary carcinoma stem cells was resistant to chemotherapy and radiation, possibly due to aberrant activation of the ATM/p53 DNA damage pathway. Epithelial-mesenchymal transition was a feature of the invasive phenotype. These data demonstrate that cancer stem cells are a feature of mammary cancer in cats. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：414 / 423
页数：10
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