Applications and Potential Toxicity of Magnetic Iron Oxide Nanoparticles

被引：447

作者：

Liu, Gang ^{[1
,5
]}

Gao, Jinhao ^{[1
,2
]}

Ai, Hua ^{[3
]}

Chen, Xiaoyuan ^{[4
]}

机构：

[1] Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[3] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China

[4] NIH, LOMIN, NIBIB, Bethesda, MD 20892 USA

[5] North Sichuan Med Coll, Sichuan Key Lab Med Imaging, Nanchong 637007, Peoples R China

来源：

SMALL | 2013年 / 9卷 / 9-10期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

iron oxide nanoparticles; magnetic resonance imaging; drug delivery; gene delivery; nanotoxicity; RESONANCE-IMAGING CONTRAST; TARGETED DRUG-DELIVERY; IN-VIVO; FE3O4; NANOPARTICLES; POLYMERIC MICELLES; NONVIRAL VECTOR; CANCER-THERAPY; SIRNA DELIVERY; GENE DELIVERY; STEM-CELLS;

D O I：

10.1002/smll.201201531

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Owing to their unique physical and chemical properties, magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism, and toxicity. In this review, the updated research on the biomedical applications and potential toxicity of magnetic iron oxide nanoparticles is summarized. Much more effort is required to develop magnetic iron oxide nanoparticles with improved biocompatible surface engineering to achieve minimal toxicity, for various applications in biomedicine.

引用

页码：1533 / 1545

页数：13

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