Hepatitis B Virus Reactivation What Is the Issue, and How Should It Be Managed?

被引：19

作者：

Ekpanyapong, Sirina ^{[1
]}

Reddy, K. Rajender ^{[2
]}

机构：

[1] Vejthani Hosp, Div Gastroenterol & Hepatol, Dept Med, 1 Soi Lat Phrao 111, Bangkok 10240, Thailand

[2] Univ Penn, Div Gastroenterol & Hepatol, Dept Med, 3400 Spruce St,2 Dulles HUP, Philadelphia, PA 19104 USA

来源：

CLINICS IN LIVER DISEASE | 2020年 / 24卷 / 03期

关键词：

Hepatitis B virus; Reactivation; Immunosuppression; Hepatitis flare; Antiviral prophylaxis; IMMUNE CHECKPOINT INHIBITORS; RESOLVED HBV INFECTION; IMMUNOSUPPRESSIVE THERAPY; BREAST-CANCER; C VIRUS; CHEMOTHERAPY; RISK; LAMIVUDINE; RITUXIMAB; LYMPHOMA;

D O I：

10.1016/j.cld.2020.04.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis B virus (HBV) reactivation, in the background of cleared and overt chronic HBV infection, can be seen in patients receiving immunosuppressive agents. Risk of reactivation is variably associated with HBV serologic status and types of immunosuppressive therapy. Prevention of HBV reactivation by antiviral prophylaxis is an effective strategy to reduce morbidity and mortality in those with immunocompromised states. This article defines HBV reactivation, discusses risk stratification and common medications that can induce HBV reactivation as well as guideline recommendations for prevention of HBV reactivation, and describes the prognosis and management of patients who experience HBV reactivation.

引用

页码：317 / +

页数：18

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