Prevention of multiple sclerosis: A realistic goal?

被引：0
作者：
Vukusic, S. [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Serv Neurol A, F-69677 Lyon, France
[2] Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Fdn Eugene Dev EDMUS Sclerose Plaques, F-69677 Lyon, France
[3] Equipe Neurooncol & Neuroinflammat, Ctr Neurosci Lyon, Inserm U1028, F-69003 Lyon, France
[4] Equipe Neurooncol & Neuroinflammat, Ctr Neurosci Lyon, CNRS UMR 5292, F-69003 Lyon, France
[5] Univ Lyon, F-69003 Lyon, France
[6] Univ Lyon 1, F-69003 Lyon, France
来源：
REVUE NEUROLOGIQUE | 2012年 / 168卷 / 11期
关键词：
Multiple sclerosis; Genes; Environment; Prevention; Vitamin D; RADIOLOGICALLY ISOLATED SYNDROME; CLINICALLY ISOLATED SYNDROMES; ENVIRONMENTAL RISK-FACTORS; VITAMIN-D INSUFFICIENCY; FOLLOW-UP; DIAGNOSTIC-CRITERIA; OPTIC NEURITIS; PREDICT CONVERSION; MRI CRITERIA; SEX-RATIO;
D O I：
10.1016/j.neurol.2012.07.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Multiple sclerosis (MS) is the most frequent source of chronic neurological disability in Western countries, and its incidence and prevalence are increasing. However, it is possible to determine its prodromal phase and the radiological, biological and immunological endophenotypes that are present before the clinical onset of the disease, despite remaining unseen with the naked eye. In this context, greater knowledge of the aetiological factors, both genetic and environmental, may lead the way towards primary prevention strategies for MS in the near future. (C) 2012 Published by Elsevier Masson SAS.
引用
收藏
页码：836 / 845
页数：10
相关论文
共 69 条
  • [41] Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
    McDonald, WI
    Compston, A
    Edan, G
    Goodkin, D
    Hartung, HP
    Lublin, FD
    McFarland, HF
    Paty, DW
    Polman, CH
    Reingold, SC
    Sandberg-Wollheim, M
    Sibley, W
    Thompson, AJ
    van den Noort, S
    Weinshenker, BY
    Wolinsky, JS
    [J]. ANNALS OF NEUROLOGY, 2001, 50 (01) : 121 - 127
  • [42] Clinical presentation of primary progressive multiple sclerosis 10 years after the incidental finding of typical magnetic resonance imaging brain lesions - The subclinical stage of primary progressive multiple sclerosis may last 10 years
    McDonnell, GV
    Cabrera-Gomez, J
    Calne, DB
    Li, DKB
    Oger, J
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2003, 9 (02) : 204 - 209
  • [43] Time of Birth, Residential Solar Radiation and Age at Onset of Multiple Sclerosis
    McDowell, Tzu-Yun
    Amr, Sania
    Langenberg, Patricia
    Royal, Walter
    Bever, Christopher
    Culpepper, William J.
    Bradham, Douglas D.
    [J]. NEUROEPIDEMIOLOGY, 2010, 34 (04) : 238 - 244
  • [44] Clinically isolated syndromes suggestive of multiple sclerosis, part 1: natural history, pathogenesis, diagnosis, and prognosis
    Miller, D
    Barkhof, F
    Montalban, X
    Thompson, A
    Filippi, M
    [J]. LANCET NEUROLOGY, 2005, 4 (05) : 281 - 288
  • [45] Gestational Vitamin D and the Risk of Multiple Sclerosis in Offspring
    Mirzaei, Fariba
    Michels, Karin B.
    Munger, Kassandra
    O'Reilly, Eilis
    Chitnis, Tanuja
    Forman, Michele R.
    Giovannucci, Edward
    Rosner, Bernard
    Ascherio, Alberto
    [J]. ANNALS OF NEUROLOGY, 2011, 70 (01) : 30 - 40
  • [46] Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    Munger, Kassandra L.
    Levin, Lynn I.
    Hollis, Bruce W.
    Howard, Noel S.
    Ascherio, Alberto
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (23): : 2832 - 2838
  • [47] Vitamin D intake and incidence of multiple sclerosis
    Munger, KL
    Zhang, SM
    O'Reilly, E
    Hernán, MA
    Olek, MJ
    Willett, WC
    Ascherio, A
    [J]. NEUROLOGY, 2004, 62 (01) : 60 - 65
  • [48] Incidental MRI anomalies suggestive of multiple sclerosis The radiologically isolated syndrome
    Okuda, D. T.
    Mowry, E. M.
    Beheshtian, A.
    Waubant, E.
    Baranzini, S. E.
    Goodin, D. S.
    Hauser, S. L.
    Pelletier, D.
    [J]. NEUROLOGY, 2009, 72 (09) : 800 - 805
  • [49] Association of UV radiation with multiple sclerosis prevalence and sex ratio in France
    Orton, S. -M.
    Wald, L.
    Confavreux, C.
    Vukusic, S.
    Krohn, J. P.
    Ramagopalan, S. V.
    Herrera, B. M.
    Sadovnick, A. D.
    Ebers, G. C.
    [J]. NEUROLOGY, 2011, 76 (05) : 425 - 431
  • [50] Sex ratio of multiple sclerosis in Canada: a longitudinal study
    Orton, Sarah-Michelle
    Herrera, Blanca M.
    Yee, Irene M.
    Valdar, William
    Ramagopalan, Sreeram V.
    Sadovnick, A. Dessa
    Ebers, George C.
    [J]. LANCET NEUROLOGY, 2006, 5 (11) : 932 - 936
1234567