Removal of epidural catheter under dual antiplatelet therapy following acute coronary syndrome

被引：0

作者：

Limper, U. ^{[1
]}

Lynch, J. ^{[2
]}

机构：

[1] Univ Witten Herdecke, Klin Anasthesiol & Operat Intens Med, Krankenhaus Koln Merheim, Kliniken Stadt Koln gGmbH,Lehrstuhl Anasthesiol 2, D-51109 Cologne, Germany

[2] Krankenhaus Koln Holweide, Abt Anasthesiol & Operat Intens Med, Cologne, Germany

来源：

ANAESTHESIST | 2012年 / 61卷 / 08期

关键词：

Clopidogrel; Myocardial infarction; Perioperative period; Proton pump inhibitors; Drug interactions; DIABETES-MELLITUS; PLATELET-AGGREGATION; STENT THROMBOSIS; CLOPIDOGREL; PHARMACOKINETICS; AGGREGOMETRY; ASSOCIATION; REACTIVITY; ASPIRIN; PATIENT;

D O I：

10.1007/s00101-012-2067-4

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

This article reports the case of a patient who developed acute coronary syndrome while receiving postoperative pain treatment via an epidural catheter (EC). Platelet function testing was performed before removal of the EC to assess the bleeding risk under ongoing dual antiplatelet therapy. Platelet function testing showed low responsiveness to clopidogrel and acetylsalicylic acid (ASS). The EC was removed uneventfully and clopidogrel was subsequently replaced by prasugrel and platelet function showed improved depression of thrombocyte aggregation. Possible reasons for low responsiveness to clopidogrel and ASS, such as drug-drug interactions with proton pump inhibitors and genetic factors are discussed.

引用

收藏

页码：686 / 690

页数：5

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