A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2

被引：30
|
作者：
Bhattacharya, Rajarshi [1 ]
Gupta, Aayatti Mallick [2 ]
Mitra, Suranjita [1 ]
Mandal, Sukhendu [3 ]
Biswas, Swadesh R. [1 ]
机构：
[1] Visva Bharati, Dept Bot, Santini Ketan 731235, W Bengal, India
[2] S N Bose Natl Ctr Basic Sci, Dept Chem Biol & Macro Mol Sci, Block JD,Sector III, Kolkata 700106, India
[3] Univ Calcutta, Dept Microbiol, Lab Mol Bacteriol, 35 Ballygunge Circular Rd, Kolkata 700019, India
来源：
VIROLOGY | 2021年 / 552卷
关键词：
Nisin; SARS-CoV-2; COVID-19; Human ACE2 receptor; Molecular docking; Therapeutics; INHIBITORS;
D O I：
10.1016/j.virol.2020.10.002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Nisin, a food-grade antimicrobial peptide produced by lactic acid bacteria has been examined for its probable interaction with the human ACE2 (hACE2) receptor, the site where spike protein of SARS-CoV-2 binds. Among the eight nisin variants examined, nisin H, nisin Z, nisin U and nisin A showed a significant binding affinity towards hACE2, higher than that of the RBD (receptor binding domain) of the SARS-CoV-2 spike protein. The molecular interaction of nisin with hACE2 was investigated by homology modeling and docking studies. Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. Here, nisin H acted as a potential competitor of RBD to access the hACE2 receptor. The study unravels for the first time that a globally used food preservative, nisin has the potential to bind to hACE2.
引用
收藏
页码：107 / 111
页数：5
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