A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2

被引：29

作者：

Bhattacharya, Rajarshi ^{[1
]}

Gupta, Aayatti Mallick ^{[2
]}

Mitra, Suranjita ^{[1
]}

Mandal, Sukhendu ^{[3
]}

Biswas, Swadesh R. ^{[1
]}

机构：

[1] Visva Bharati, Dept Bot, Santini Ketan 731235, W Bengal, India

[2] S N Bose Natl Ctr Basic Sci, Dept Chem Biol & Macro Mol Sci, Block JD,Sector III, Kolkata 700106, India

[3] Univ Calcutta, Dept Microbiol, Lab Mol Bacteriol, 35 Ballygunge Circular Rd, Kolkata 700019, India

来源：

VIROLOGY | 2021年 / 552卷

关键词：

Nisin; SARS-CoV-2; COVID-19; Human ACE2 receptor; Molecular docking; Therapeutics; INHIBITORS;

D O I：

10.1016/j.virol.2020.10.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nisin, a food-grade antimicrobial peptide produced by lactic acid bacteria has been examined for its probable interaction with the human ACE2 (hACE2) receptor, the site where spike protein of SARS-CoV-2 binds. Among the eight nisin variants examined, nisin H, nisin Z, nisin U and nisin A showed a significant binding affinity towards hACE2, higher than that of the RBD (receptor binding domain) of the SARS-CoV-2 spike protein. The molecular interaction of nisin with hACE2 was investigated by homology modeling and docking studies. Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. Here, nisin H acted as a potential competitor of RBD to access the hACE2 receptor. The study unravels for the first time that a globally used food preservative, nisin has the potential to bind to hACE2.

引用

页码：107 / 111

页数：5

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