Recent development of aptamer conjugated chitosan nanoparticles as cancer therapeutics

被引：51
作者：
Sheikh, Afsana [1 ]
Md, Shadab [2 ,3 ]
Alhakamy, Nabil A. [2 ,3 ]
Kesharwani, Prashant [1 ]
机构：
[1] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India
[2] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia
[3] King Abdulaziz Univ, Ctr Excellence Drug Res & Pharmaceut Ind, Jeddah 21589, Saudi Arabia
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2022年 / 620卷
关键词：
Aptamer; Chitosan; Nanoparticles; Cancer; Targeted therapy; Toxicity; Gene delivery; Nanomedicine; TARGETED DRUG-DELIVERY; ANTI-VEGF APTAMER; IN-VITRO; DNA APTAMER; RNA APTAMER; BIOMEDICAL APPLICATIONS; PROMISING NANOCARRIERS; GOLD NANOPARTICLES; PAMAM DENDRIMERS; MOLECULAR PROBES;
D O I：
10.1016/j.ijpharm.2022.121751
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
There is a surge in demand for safe and targeted therapy against cancer as the conventional treatment approach fails to reach the specific site. Chemotherapeutic agents are generally associated with low tumoral accumulation, off-site effect, and drug resistance. Targeted delivery with the use of nanocarrier could elevate the drug accumulation at the target site, reduce toxicity to non-cancerous cells, overcome drug resistance, and reduce dosing. Aptamers are single-stranded oligonucleotide that folds in a way to get into the pocket of target cells with high affinity and specificity due to the ability to recognize and interact with the biomarkers such as nucleolin, Mucin, EGFR, etc. overexpressed by cancer cells. Aptamer also plays a key role in cancer immunotherapy and the delivery of anti-cancer agents. The review brings the light upon the use of aptamer-chitosan nanoparticles against cancer therapy and their role in the reduction of toxic effects.
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页数：16
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