Novel approaches for the identification of biomarkers of aggressive prostate cancer

被引：10

作者：

Kim, Yunee ^{[1
]}

Kislinger, Thomas ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada

[2] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada

来源：

GENOME MEDICINE | 2013年 / 5卷

关键词：

TMPRSS2-ERG FUSION TRANSCRIPTS; MEMBRANE ANTIGEN-EXPRESSION; METHYLACYL-COA RACEMASE; N-LINKED GLYCOPROTEINS; BEAM RADIATION-THERAPY; RADICAL PROSTATECTOMY; TELOMERASE ACTIVITY; URINARY EXOSOMES; TUMOR-CELLS; BONE-MARROW;

D O I：

10.1186/gm460

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The ability to distinguish indolent from aggressive prostate tumors remains one of the greatest challenges in the management of this disease. Ongoing efforts to establish a panel of molecular signatures, comprising gene expression profiles, proteins, epigenetic patterns, or a combination of these alterations, are being propelled by rapid advancements in 'omics' technologies. The identification of such biomarkers in biological fluids is an especially attractive goal for clinical applications. Here, we summarize recent progress in the identifi cation of candidate prognostic biomarkers of prostate cancer using biological fluid samples.

引用

页数：11

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