A novel acylated quercetin glycoside and compounds of inhibitory effects on α-glucosidase from Panax ginseng flower buds

被引：8
|
作者：
Li, Keke [1 ]
Li, Shasha [2 ]
Xu, Fei [2 ]
Cao, Guiyun [3 ]
Gong, Xiaojie [1 ]
机构：
[1] Dalian Minzu Univ, Coll Life Sci, Dept Biol Engn, Dalian, Peoples R China
[2] Dalian Univ, Coll Med, Dalian, Peoples R China
[3] Shandong Hongjitang Pharmaceut Grp Co Ltd, Jinan, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 18期
基金：
中国国家自然科学基金;
关键词：
acylated quercetin glycoside; flavonoids; floralpanasenoside A; alpha-glucosidase inhibition; Panax ginseng; LEAVES; TRITERPENOIDS; FLAVONOIDS; SAPONINS; STEMS;
D O I：
10.1080/14786419.2018.1543685
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel acylated quercetin glycoside, floralpanasenoside A (1) and five known flavonoid glycosides, panasenoside (2), quercetin 3-O-(2''-beta-D-glucopyranosyl)-beta-D-galactopyranoside (3), trifolin (4) kaempferol 7-O-alpha-L-rhamnoside (5), and afzelin (6) were isolated from the flower buds ofPanax ginseng. Their structures were established by spectroscopic data and comparison with the literature values. Four of the six isolated compounds including1(IC50= 62.4) exhibited alpha-glucosidase inhibitory activity with IC50 values lower than acarbose (385.2 mu M). The molecular docking study indicated that1bound to the active site of alpha-glucosidase with numerous hydrogen bond interactions. [GRAPHICS] .
引用
收藏
页码：2559 / 2565
页数：7
相关论文
共 50 条
  • [31] A Strategy for Simultaneous Isolation of Less Polar Ginsenosides, Including a Pair of New 20-Methoxyl Isomers, from Flower Buds of Panax ginseng
    Li, Sha-Sha
    Li, Ke-Ke
    Xu, Fei
    Tao, Li
    Yang, Li
    Chen, Shu-Xiao
    Gong, Xiao-Jie
    MOLECULES, 2017, 22 (03)
  • [32] Medicinal Flowers. XXXVI. Acylated Oleanane-Type Triterpene Saponins with Inhibitory Effects on Melanogenesis from the Flower Buds of Chinese Camellia japonica
    Nakamura, Seikou
    Fujimoto, Katsuyoshi
    Nakashima, Souichi
    Matsumoto, Takahiro
    Miura, Tomoko
    Uno, Kaoru
    Matsuda, Hisashi
    Yoshikawa, Masayuki
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, 60 (06) : 752 - 758
  • [33] Structure of constituents isolated from the flower buds of Cananga odorata and their inhibitory effects on aldose reductase
    Matsumoto, Takahiro
    Nakamura, Seikou
    Fujimoto, Katsuyoshi
    Ohta, Tomoe
    Ogawa, Keiko
    Yoshikawa, Masayuki
    Matsuda, Hisashi
    JOURNAL OF NATURAL MEDICINES, 2014, 68 (04) : 709 - 716
  • [34] Structure of constituents isolated from the flower buds of Cananga odorata and their inhibitory effects on aldose reductase
    Takahiro Matsumoto
    Seikou Nakamura
    Katsuyoshi Fujimoto
    Tomoe Ohta
    Keiko Ogawa
    Masayuki Yoshikawa
    Hisashi Matsuda
    Journal of Natural Medicines, 2014, 68 : 709 - 716
  • [35] Medicinal flowers.: XI.: Structures of new dammarane-type triterpene diglycosides with hydroperoxide group from flower buds of Panax ginseng
    Yoshikawa, Masayuki
    Sugimoto, Sachiko
    Nakamura, Seikou
    Matsuda, Hisash
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (04) : 571 - 576
  • [36] Application of Large-Scale Molecular Prediction for Creating the Preferred Precursor Ions List to Enhance the Identification of Ginsenosides from the Flower Buds of Panax ginseng
    Zhang, Chunxia
    Liu, Meiyu
    Xu, Xiaoyan
    Wu, Jia
    Li, Xue
    Wang, Hongda
    Gao, Xiumei
    Guo, Dean
    Tian, Xiaoxuan
    Yang, Wenzhi
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2022, 70 (19) : 5932 - 5944
  • [37] Antioxidative effects of quercetin-glyco sides isolated from the flower buds of Tussilago farfara L.
    Kim, Mi-Ran
    Lee, Jeong Yong
    Lee, Hyang-Hee
    Aryal, Dipendra Kuma
    Kim, Yoon Gyoon
    Kim, Sang Kyum
    Woo, Eun-Rhan
    Kang, Keon Wook
    FOOD AND CHEMICAL TOXICOLOGY, 2006, 44 (08) : 1299 - 1307
  • [38] Complete 1H-NMR and 13C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng
    Wang, Yu-Shuai
    Jin, Yin-Ping
    Gao, Wei
    Xiao, Sheng-Yuan
    Zhang, Yu-Wei
    Zheng, Pei-He
    Wang, Jia
    Liu, Jun-Xia
    Sun, Cheng-He
    Wang, Ying-Ping
    JOURNAL OF GINSENG RESEARCH, 2016, 40 (03) : 245 - 250
  • [39] Medicinal flowers.: XVII.: New dammarane-type triterpene glycosides from flower buds of American ginseng, Panax quinquefolium L.
    Nakamura, Setkou
    Sugimoto, Sachiko
    Matsuda, Hisashi
    Yoshikawa, Masayuki
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (09) : 1342 - 1348
  • [40] An off-line three-dimensional liquid chromatography/Q-Orbitrap mass spectrometry approach enabling the discovery of 1561 potentially unknown ginsenosides from the flower buds of Panax ginseng, Panax quinquefolius and Panax notoginseng
    Jia, Li
    Wang, Hongda
    Xu, Xiaoyan
    Wang, Huimin
    Li, Xue
    Hu, Ying
    Chen, Boxue
    Liu, Meiyu
    Gao, Xiumei
    Li, Huifang
    Guo, Dean
    Yang, Wenzhi
    JOURNAL OF CHROMATOGRAPHY A, 2022, 1675
12345