A novel acylated quercetin glycoside and compounds of inhibitory effects on α-glucosidase from Panax ginseng flower buds

被引：8

作者：

Li, Keke ^{[1
]}

Li, Shasha ^{[2
]}

Xu, Fei ^{[2
]}

Cao, Guiyun ^{[3
]}

Gong, Xiaojie ^{[1
]}

机构：

[1] Dalian Minzu Univ, Coll Life Sci, Dept Biol Engn, Dalian, Peoples R China

[2] Dalian Univ, Coll Med, Dalian, Peoples R China

[3] Shandong Hongjitang Pharmaceut Grp Co Ltd, Jinan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 18期

基金：

中国国家自然科学基金;

关键词：

acylated quercetin glycoside; flavonoids; floralpanasenoside A; alpha-glucosidase inhibition; Panax ginseng; LEAVES; TRITERPENOIDS; FLAVONOIDS; SAPONINS; STEMS;

D O I：

10.1080/14786419.2018.1543685

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel acylated quercetin glycoside, floralpanasenoside A (1) and five known flavonoid glycosides, panasenoside (2), quercetin 3-O-(2''-beta-D-glucopyranosyl)-beta-D-galactopyranoside (3), trifolin (4) kaempferol 7-O-alpha-L-rhamnoside (5), and afzelin (6) were isolated from the flower buds ofPanax ginseng. Their structures were established by spectroscopic data and comparison with the literature values. Four of the six isolated compounds including1(IC50= 62.4) exhibited alpha-glucosidase inhibitory activity with IC50 values lower than acarbose (385.2 mu M). The molecular docking study indicated that1bound to the active site of alpha-glucosidase with numerous hydrogen bond interactions. [GRAPHICS] .

引用

页码：2559 / 2565

页数：7

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