Novel clay-mediated, tandem addition-elimination-(Michael) addition reactions of indoles with 3-formylindole: an eco-friendly route to symmetrical and unsymmetrical triindolylmethanes

被引：77
作者：
Chakrabarty, M [1 ]
Sarkar, S [1 ]
机构：
[1] Bose Inst, Dept Chem, Kolkata 700009, India
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 07期
关键词：
condensation; 3-formylindole; (alkyl)indoles; clay; triindolylmethanes;
D O I：
10.1016/S0040-4039(01)02380-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Dry reaction of 3-formylindole (1) with indole (2a) on Montmorillonite K10 clay at room temperature furnished within minutes tris(indol-3-yl)methane (3a) in high yield. The reaction of 1 with other mono- and dialkylindoles (2b-c, skatole. 8a-c) under similar conditions yielded either or both of symmetrical (3b c. 9) and unsymmetrical (4b c. 5b c. 10, 11a-c) triindolylmethanes, (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1351 / 1353
页数：3
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