Parental age as a risk factor for isolated congenital malformations in a Polish population

被引：59

作者：

Materna-Kiryluk, Anna ^{[1
]}

Wisniewska, Katarzyna ^{[1
,2
]}

Badura-Stronka, Magdalena ^{[1
]}

Mejnartowicz, Jan ^{[1
]}

Wieckowska, Barbara ^{[3
]}

Balcar-Boron, Anna ^{[5
]}

Czerwionka-Szaflarska, Mieczyslawa ^{[6
]}

Gajewska, Elzbieta ^{[7
]}

Godula-Stuglik, Urszula ^{[8
]}

Krawczynski, Marian ^{[4
]}

Limon, Janusz ^{[9
]}

Rusin, Jozef ^{[10
]}

Sawulicka-Oleszczuk, Henryka ^{[11
]}

Szwalkiewicz-Warowicka, Ewa ^{[12
]}

Walczak, Mieczyslaw ^{[13
]}

Latos-Bielenska, Anna ^{[1
]}

机构：

[1] Karol Marcinkowski Univ Med Sci, Dept Med Genet, Poznan, Poland

[2] Karol Marcinkowski Univ Med Sci, Dept Prevent Med, Poznan, Poland

[3] Karol Marcinkowski Univ Med Sci, Dept Comp Sci & Stat, Poznan, Poland

[4] Karol Marcinkowski Univ Med Sci, Dept Gastroenterol & Metab, Poznan, Poland

[5] Med Univ Bydgoszcz, Dept Paediat Haematol & Oncol, Bydgoszcz, Poland

[6] Nicholas Copernicus Univ, Coll Med, Dept Paediat Allergol & Gastroenterol, Torun, Poland

[7] Wroclaw Med Univ, Dept Neonatol, Wroclaw, Poland

[8] Med Univ Silesia, Dept Paediat 2, Katowice, Poland

[9] Med Univ Gdansk, Dept Biol & Genet, Gdansk, Poland

[10] Rzeszow Univ, Fac Med, Rzeszow, Poland

[11] Med Univ Lublin, Dept Obstet & Pathol Pregnancy, Lublin, Poland

[12] Reg Childrens Hosp, Olsztyn, Poland

[13] Pomeranian Med Univ, Dept Paediat 2, Szczecin, Poland

来源：

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY | 2009年 / 23卷 / 01期

关键词：

congenital malformations; maternal age; paternal age; ABDOMINAL-WALL DEFECTS; NEURAL-TUBE DEFECTS; SMALL-INTESTINAL ATRESIA; PATERNAL AGE; BIRTH-DEFECTS; MATERNAL AGE; DIAPHRAGMATIC-HERNIA; HEART-DEFECTS; SPINA-BIFIDA; GASTROSCHISIS;

D O I：

10.1111/j.1365-3016.2008.00979.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Currently available data on the relationship between the prevalence of isolated congenital malformations and parental age are inconsistent and frequently divergent. We utilised the data from the Polish Registry of Congenital Malformations (PRCM) to accurately assess the interplay between maternal and paternal age in the risk of isolated non-syndromic congenital malformations. Out of 902 452 livebirths we studied 8683 children aged 0-2 years registered in the PRCM. Logistic regression was used to simultaneously adjust the risk estimates for maternal and paternal age. Our data indicated that paternal and maternal age were independently associated with several congenital malformations. Based on our data, young maternal and paternal ages were independently associated with gastroschisis. In addition, young maternal age, but not young paternal age, carried a higher risk of neural tube defects. Advanced maternal and paternal ages were both independently associated with congenital heart defects. Moreover, there was a positive association between advanced paternal age and hypospadias, cleft palate, and cleft lip (with or without cleft palate). No significant relationships between parental age and the following congenital malformations were detected: microcephaly, hydrocephaly, oesophageal atresia, atresia or stenosis of small and/or large intestine, ano-rectal atresia or stenosis, renal agenesis or hypoplasia, cystic kidney disease, congenital hydronephrosis, diaphragmatic hernia and omphalocele.

引用

页码：29 / 40

页数：12

共 58 条

[1] Association of paternal age with prevalence of selected birth defects [J].