Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus

被引：58

作者：

Karimipour, Mohammad ^{[1
,2
,3
,4
]}

Rahbarghazi, Reza ^{[2
,3
]}

Tayefi, Hamid ^{[1
]}

Shimia, Mohammad ^{[5
]}

Ghanadian, Mustafa ^{[6
]}

Mahmoudi, Javad ^{[4
]}

Bagheri, Hesam Saghaei ^{[3
]}

机构：

[1] Tabriz Univ Med Sci, Fac Med, Dept Anat Sci, Tabriz, Iran

[2] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Appl Cell Sci, Tabriz, Iran

[4] Tabriz Univ Med Sci, Adv Biomed Fac, Neurosci Res Ctr, Tabriz, Iran

[5] Tabriz Univ Med Sci, Fac Med, Dept Neurosurg, Tabriz, Iran

[6] Isfahan Univ Med Sci, Fac Pharm, Pharmaceut Sci Res Ctr, Esfahan, Iran

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2019年 / 74卷

关键词：

Neural stem/progenitor cells; Cell proliferation; Neurogenesis; Quercetin; Learning and memory; Alzheimer's disease; NERVE GROWTH-FACTOR; ALZHEIMERS-DISEASE; NEUROTROPHIC-FACTOR; SYNAPTIC PLASTICITY; THERAPEUTIC TARGET; PROGENITOR CELLS; DECREASED-LEVELS; GRANULE CELLS; BRAIN; HIPPOCAMPUS;

D O I：

10.1016/j.ijdevneu.2019.02.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The decline in neurogenesis is a very critical problem in Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin. Herein, we investigated the neurogenesis potential of quercetin in a rat model of Alzheimer's disease induced by amyloid-beta injection. Rats were randomly divided into Control, Alzheimer + Saline and Alzheimer + Quercetin groups. Following the administration of Amyloid-beta, rats in the Alzheimer + Quercetin group received 40 mg/kg/day quercetin orally for one month. Our data demonstrated amyloid-beta injection could impair learning and memory processing in rats indicated by passive avoidance test evaluation. We noted that one-month quercetin treatment alleviated the detrimental effects of amyloid-beta on spatial learning and memory parameters using Morris water maze analysis. Quercetin was found to increase the number of proliferating neural stem/progenitor cells. Notably, quercetin increased the number of DCX-expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus. We further observed that the quercetin improved the number of BrdU/NeuN positive cells contributed to enhanced adult neurogenesis. Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis. These data suggest that quercetin can play a valuable role in alleviating Alzheimer's disease symptoms by enhancing adult neurogenesis mechanism.

引用

页码：18 / 26

页数：9