Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus

被引：58
作者：
Karimipour, Mohammad [1 ,2 ,3 ,4 ]
Rahbarghazi, Reza [2 ,3 ]
Tayefi, Hamid [1 ]
Shimia, Mohammad [5 ]
Ghanadian, Mustafa [6 ]
Mahmoudi, Javad [4 ]
Bagheri, Hesam Saghaei [3 ]
机构：
[1] Tabriz Univ Med Sci, Fac Med, Dept Anat Sci, Tabriz, Iran
[2] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Appl Cell Sci, Tabriz, Iran
[4] Tabriz Univ Med Sci, Adv Biomed Fac, Neurosci Res Ctr, Tabriz, Iran
[5] Tabriz Univ Med Sci, Fac Med, Dept Neurosurg, Tabriz, Iran
[6] Isfahan Univ Med Sci, Fac Pharm, Pharmaceut Sci Res Ctr, Esfahan, Iran
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2019年 / 74卷
关键词：
Neural stem/progenitor cells; Cell proliferation; Neurogenesis; Quercetin; Learning and memory; Alzheimer's disease; NERVE GROWTH-FACTOR; ALZHEIMERS-DISEASE; NEUROTROPHIC-FACTOR; SYNAPTIC PLASTICITY; THERAPEUTIC TARGET; PROGENITOR CELLS; DECREASED-LEVELS; GRANULE CELLS; BRAIN; HIPPOCAMPUS;
D O I：
10.1016/j.ijdevneu.2019.02.005
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The decline in neurogenesis is a very critical problem in Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin. Herein, we investigated the neurogenesis potential of quercetin in a rat model of Alzheimer's disease induced by amyloid-beta injection. Rats were randomly divided into Control, Alzheimer + Saline and Alzheimer + Quercetin groups. Following the administration of Amyloid-beta, rats in the Alzheimer + Quercetin group received 40 mg/kg/day quercetin orally for one month. Our data demonstrated amyloid-beta injection could impair learning and memory processing in rats indicated by passive avoidance test evaluation. We noted that one-month quercetin treatment alleviated the detrimental effects of amyloid-beta on spatial learning and memory parameters using Morris water maze analysis. Quercetin was found to increase the number of proliferating neural stem/progenitor cells. Notably, quercetin increased the number of DCX-expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus. We further observed that the quercetin improved the number of BrdU/NeuN positive cells contributed to enhanced adult neurogenesis. Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis. These data suggest that quercetin can play a valuable role in alleviating Alzheimer's disease symptoms by enhancing adult neurogenesis mechanism.
引用
收藏
页码：18 / 26
页数：9
相关论文
共 50 条
[31]   Effects of sleep deprivation and recovery sleep upon cell proliferation in adult rat dentate gyrus [J].
Tung, A ;
Takase, L ;
Fornal, C ;
Jacobs, B .
NEUROSCIENCE, 2005, 134 (03) :721-723
[32]   Fluoxetine or Sox2 reactivate proliferation-defective stem and progenitor cells of the adult and aged dentate gyrus [J].
Micheli, Laura ;
Ceccarelli, Manuela ;
D'Andrea, Giorgio ;
Costanzi, Marco ;
Giacovazzo, Giacomo ;
Coccurello, Roberto ;
Caruso, Carla ;
Tirone, Felice .
NEUROPHARMACOLOGY, 2018, 141 :316-330
[33]   Neural precursor proliferation and newborn cell survival in the adult rat dentate gyrus are affected by vitamin E deficiency [J].
Ciaroni, S ;
Cecchini, T ;
Ferri, P ;
Cuppini, R ;
Ambrogini, P ;
Santi, S ;
Benedetti, S ;
Del Grande, P ;
Papa, S .
NEUROSCIENCE RESEARCH, 2002, 44 (04) :369-377
[34]   Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors [J].
Cicvaric, Ana ;
Sachernegg, Hannah M. ;
Stojanovic, Tamara ;
Symmank, Doerte ;
Smani, Tarik ;
Moeslinger, Thomas ;
Uhrin, Pavel ;
Monje, Francisco J. .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 13
[35]   Reversible effect of X-irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice [J].
Ben Abdallah, Nada M. -B. ;
Slomianka, Lutz ;
Lipp, Hans-Peter .
HIPPOCAMPUS, 2007, 17 (12) :1230-1240
[36]   The sphingosine-1-phosphate analogue, FTY-720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis and learning and memory abilities in adult mice [J].
Sun, Yili ;
Hong, Feng ;
Zhang, Lei ;
Feng, Linyin .
BRITISH JOURNAL OF PHARMACOLOGY, 2016, 173 (18) :2793-2807
[37]   Additive or Synergistic Effects of Aluminum on the Reduction of Neural Stem Cells, Cell Proliferation, and Neuroblast Differentiation in the Dentate Gyrus of High-Fat Diet-Fed Mice [J].
Nam, Sung Min ;
Kim, Jong Whi ;
Yoo, Dae Young ;
Kim, Woosuk ;
Jung, Hyo Young ;
Hwang, In Koo ;
Seong, Je Kyung ;
Yoon, Yeo Sung .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2014, 157 (01) :51-59
[38]   Trideoxycytidine Diphosphate Promotes Neural Stem Cell Proliferation and Neurogenesis in Mice [J].
Ishimoto, Takahiro ;
Hayashi, Fuyu ;
Yamamoto, Yuya ;
Kiriyama, Keisuke ;
Yamashita, Reiya ;
Matsumura, Naoto ;
Nishiuchi, Takumi ;
Masuo, Yusuke ;
Fujita, Mica ;
Sutoh, Keita ;
Kato, Yukio .
JOURNAL OF NUTRITION, 2025, 155 (02) :643-654
[39]   The effects of BR003 on memory and cell proliferation in the dentate gyrus of rat hippocampus [J].
Oh, MS ;
Park, C ;
Huh, Y ;
Kim, HY ;
Kim, H ;
Kim, HM ;
Bae, H ;
Ahn, DK ;
Park, WS ;
Park, SK .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (04) :813-816
[40]   SEASONAL AND SEX DIFFERENCES IN CELL PROLIFERATION, NEUROGENESIS, AND CELL DEATH WITHIN THE DENTATE GYRUS OF ADULT WILD-CAUGHT MEADOW VOLES [J].
Spritzer, Mark D. ;
Panning, Alyssa W. ;
Engelman, Shannon M. ;
Prince, W. Tyler ;
Casler, Alexander E. ;
Georgakas, Joanna E. ;
Jaeger, Eliza C. B. ;
Nelson, Laura R. ;
Roy, Ethan A. ;
Wagner, Benjamin A. .
NEUROSCIENCE, 2017, 360 :155-165
12345