Concise Review: Immunomodulatory Properties of Mesenchymal Stem Cells in Cellular Transplantation: Update, Controversies, and Unknowns

被引：57

作者：

Atoui, Rony ^{[1
]}

Chiu, Ray C. J. ^{[2
]}

机构：

[1] Sudbury Reg Hosp, Div Cardiac Surg, Sudbury, ON P3E 3Y9, Canada

[2] McGill Univ, Ctr Hlth, Div Cardiac Surg, Montreal, PQ, Canada

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2012年 / 1卷 / 03期

关键词：

Immunogenicity; Immunosuppression; Marrow stromal stem cells; Mesenchymal stem cells; Stem cell transplantation; MARROW STROMAL CELLS; MYOCARDIAL REGENERATIVE THERAPY; VERSUS-HOST-DISEASE; INTRAMYOCARDIAL INJECTION; IMMUNE TOLERANCE; PROLIFERATION; MODEL; DIFFERENTIATION; MATURATION; ENGRAFT;

D O I：

10.5966/sctm.2011-0012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cell transplantation is a promising approach for improving cardiac function after severe myocardial damage, for which the use of autologous donor cells has been preferred to avoid immune rejection. Recently, however, rodent as well as human mesenchymal stem cells have been reported to be uniquely immune-tolerant, in both in vitro and in vivo transplant models. In this review, we explore in detail the current understanding of the underlying immunologic mechanisms, which can facilitate the use of such cells as "universal donor cells" with fascinating clinical implications. STEM CELLS TRANSLATIONAL MEDICINE 2012;1:200-205

引用

页码：200 / 205

页数：6

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