Iron and ADHD: Time to Move Beyond Serum Ferritin Levels

被引：40

作者：

Donfrancesco, Renato ^{[1
]}

Parisi, Pasquale ^{[2
]}

Vanacore, Nicola ^{[3
]}

Martines, Francesca ^{[1
]}

Sargentini, Vittorio ^{[4
,5
]}

Cortese, Samuele ^{[6
,7
]}

机构：

[1] IS Pertini Hosp, ASL RM B, Rome, Italy

[2] Univ Roma La Sapienza, Rome, Italy

[3] Natl Inst Hlth, Natl Ctr Epidemiol Surveillance & Hlth Promot, Rome, Italy

[4] ASL RM A, Rome, Italy

[5] NYU, Ctr Child Study, New York, NY 10016 USA

[6] Univ Tours, UMR S INSERM 930, CNRS ERL 3106, Child Psychiat Ctr,Univ Hosp, Tours, France

[7] Univ Verona, I-37100 Verona, Italy

来源：

JOURNAL OF ATTENTION DISORDERS | 2013年 / 17卷 / 04期

关键词：

ADHD; iron; ferritin; DEFICIT HYPERACTIVITY DISORDER; RESTLESS LEGS SYNDROME; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SYMPTOM RATINGS; CHILDREN; SUPPLEMENTATION; ASSOCIATION; ADULTS; AGE;

D O I：

10.1177/1087054711430712

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: (a) To compare serum ferritin levels in a sample of stimulant-naive children with ADHD and matched controls and (b) to assess the association of serum ferritin to ADHD symptoms severity, ADHD subtypes, and IQ. Method: The ADHD and the control groups included 101 and 93 children, respectively. Serum ferritin levels were determined with the enzyme-linked immunosorbent assay method. Results: Serum ferritin did not significantly differ between children with ADHD and controls, as well as among ADHD subtypes. Correlations between serum ferritin levels and measures related to IQ or ADHD severity were not significant. Conclusion: This is the largest controlled study that assessed ferritin levels in stimulant-naive ADHD children. The findings of this study do not support a significant relationship between serum ferritin levels and ADHD. However, the authors' results based on peripheral measures of iron do not rule out a possible implication of brain iron deficiency in ADHD, grounded on neurobiological hypotheses and preliminary empirical evidence.

引用

页码：347 / 357

页数：11

共 49 条

[1] T2 relaxation rate as an index of pituitary iron overload in patients with β-thalassemia major [J].