Lynamicins A-E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

被引：101

作者：

McArthur, Katherine A. ^{[1
]}

Mitchell, Scott S. ^{[1
]}

Tsueng, Ginger ^{[1
]}

Rheingold, Arnold ^{[2
]}

White, Donald J. ^{[1
]}

Grodberg, Jennifer ^{[1
]}

Lam, Kin S. ^{[1
]}

Potts, Barbara C. M. ^{[1
]}

机构：

[1] Nereus Pharmaceut Inc, San Diego, CA 92121 USA

[2] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 10期

关键词：

D O I：

10.1021/np800286d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of chlorinated bisindole pyrroles, lynamicins A-E (1-5), was discovered from a novel marine actinomycete. NPS12745. which was isolated from a marine sediment collected off the coast of San Diego, California. Close to full length 16S rRNA sequence analysis indicated that NPS12745 is a novel strain of a recently described marine actinomycete with the proposed genus name Marinispora. The antimicrobial spectrum of these compounds was evaluated against a panel of 11 pathogens. which demonstrated that these substances possess broad-spectrum activity against both Gram-positive and Gram-negative organisms. Significantly, compounds 1-5 were active against drug-resistant pathogens Such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.

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页码：1732 / 1737

页数：6

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