Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease

被引：61

作者：

Newman, Krista M. ^{[1
]}

Rank, Kevin M. ^{[1
]}

Vaughn, Byron P. ^{[1
]}

Khoruts, Alexander ^{[1
,2
]}

机构：

[1] Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Immunol & Biotechnol Inst, Twin Cities Campus, Minneapolis, MN USA

来源：

GUT MICROBES | 2017年 / 8卷 / 03期

关键词：

Crohn's disease; clostridium difficile; inflammatory bowel disease; fecal microbiota transplantation; ulcerative colitis; ULCERATIVE-COLITIS; IMPACT; CARRIAGE; TOXIN; RISK;

D O I：

10.1080/19490976.2017.1279377

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We recently compared results of fecal microbiota transplantation (FMT) in patients with refractory, recurrent Clostridium difficile infection (rCDI), with and without underlying inflammatory bowel disease (IBD). Here we extend this cohort and analyze outcomes in greater detail by subtype of IBD. We find that FMT is generally effective in breaking the cycle of CDI recurrence, but its effects on overall IBD progression are much less predictable. We discuss several challenges intrinsic to this complex clinical situation and outline the next steps that can address these challenges going forward.

引用

页码：303 / 309

页数：7

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