Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

被引：435

作者：

Qureshi, Irfan A. ^{[1
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]}

Mehler, Mark F. ^{[1
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]}

机构：

[1] Albert Einstein Coll Med, Roslyn & Leslie Goldstein Lab Stem Cell Biol & Re, New York, NY 10461 USA

[2] Albert Einstein Coll Med, Inst Brain Disorders & Neural Regenerat, New York, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Neurol, New York, NY 10461 USA

[4] Albert Einstein Coll Med, Dept Neurosci, New York, NY 10461 USA

[5] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, New York, NY 10461 USA

[6] Albert Einstein Coll Med, Rose F Kennedy Ctr Res Intellectual & Dev Disabil, New York, NY 10461 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2012年 / 13卷 / 08期

基金：

美国国家卫生研究院;

关键词：

REPEAT-CONTAINING RNA; GENE-EXPRESSION; MICRORNA EXPRESSION; OLIGODENDROCYTE DIFFERENTIATION; BIDIRECTIONAL TRANSCRIPTION; MAMMALIAN TRANSCRIPTOME; SYNAPTIC PLASTICITY; HUNTINGTONS-DISEASE; RETINAL DEVELOPMENT; ENDOGENOUS SIRNAS;

D O I：

10.1038/nrn3234

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture, regulation and transcriptional output, as well as by innovations in sequencing technologies and computational and systems biology. These ncRNAs can interact with DNA, RNA and protein molecules; engage in diverse structural, functional and regulatory activities; and have roles in nuclear organization and transcriptional, post-transcriptional and epigenetic processes. This expanding inventory of ncRNAs is implicated in mediating a broad spectrum of processes including brain evolution, development, synaptic plasticity and disease pathogenesis.

引用

收藏

页码：528 / 541

页数：14

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