CD14 receptor gene promoter polymorphism: Awakening maternal immunity during pregnancy

被引：1
作者：
Lim, J. E.
Kim, T.
Lee, N. W.
Oh, M. J.
Seol, H. J.
Min, J. Y.
Kim, H. J.
机构：
[1] Korea Univ, Sch Med, Ansan Hosp, Dept Obstet & Gynaecol, Ansan 425707, Gyeonggi, South Korea
[2] Korea Univ, Sch Med, Guro Hosp, Seoul 136701, South Korea
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2006年 / 34卷 / 02期
关键词：
pre-eclampsia; pregnant women; immune system; monocyte; CD14; receptor; polymorphism;
D O I：
10.1177/147323000603400207
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We investigated whether monocyte CD14 receptor gene promoter polymorphisms were associated with the development and severity of pre-eclampsia. We genotyped the CD14-260 C/T polymorphism in 36 pre-eclamptic patients and 52 healthy pregnant controls. A total of 30.6% and 69.4% of pre-eclamptic patients had the C and T alleles, respectively, and 48.0% and 52.0% of the controls, respectively. More pre-eclamptic patients were TT homozygotes compared with controls (50.0% versus 13.5%). In pre-eclamptic patients, the TT homozygotes exhibited a significantly higher mean systolic blood pressure compared with the non-TT homozygotes (173 +/- 28 mmHg versus 153 +/- 22 mmHg). We also noted a tendency towards increased proteinuria and placental abruption in the TT homozygotes compared with the non-TT homozygotes. We conclude that CD14 gene promoter polymorphisms appear to be a risk factor for pre-eclampsia. With further research, these findings might form the basis of a prognostic tool for pre-eclampsia.
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收藏
页码：176 / 182
页数：7
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