Synthesis and Anti-Liver Cancer Activity of a Novel Heterocycles Compound

被引：0

作者：

Jia, Ming-Guang ^{[1
]}

Gao, Lei ^{[2
]}

机构：

[1] Peoples Hosp Linzi Dist, Dept Hepatobiliary Surg, Zibo, Shandong, Peoples R China

[2] Peoples Hosp Linzi Dist, Dept Pediat, Ward 2, Zibo, Shandong, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 08期

关键词：

anti-liver cancer activity; novel heterocycles compound; synthesis;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new heterocycles compound (S)-2-(1-amino-propyl)-5-fluoro-3-phenyl-3H-quinazolin-4-one trifluoroacetate (1), designed using 2-fluoro-6-nitro-benzonic acid (2) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, H-1 NMR, and single crystal X-ray crystallography. In addition, in vitro anticancer activity of the title compound (1) on three human liver cancer cells (HCCLM3, SMMC-7721 and HB611) was further determined.

引用

页码：1675 / 1679

页数：5

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