Epstein-Barr virus and methotrexate-related CNS lymphoma in a patient with rheumatoid arthritis

被引：16

作者：

Migita, Kiyoshi ^{[1
]}

Miyashita, Taiichiro ^{[1
]}

Mijin, Toma ^{[1
]}

Sakito, Sohko ^{[2
]}

Kurohama, Hirokazu ^{[3
]}

Ito, Masahiro ^{[3
]}

Toda, Keisuke ^{[4
]}

Tsustumi, Keisuke ^{[4
]}

Baba, Hiroshi ^{[4
]}

Izumi, Yasumori ^{[1
]}

Kawakami, Atsushi ^{[5
]}

Niino, Daisuke ^{[6
]}

Ohshima, Kouichi ^{[6
]}

机构：

[1] NHO Natl Nagasaki Med Ctr, Dept Gen Internal Med & Rheumatol, Clin Res Ctr, Omura 8568652, Japan

[2] Sadamatsu Hosp, Dept Rheumatol, Omura 8500034, Japan

[3] NHO Natl Nagasaki Med Ctr, Dept Pathol, Omura 8568652, Japan

[4] NHO Natl Nagasaki Med Ctr, Dept Neurosurg, Omura 8568652, Japan

[5] Nagasaki Univ Hosp, Dept Rheumatol, Nagasaki, Japan

[6] Kurume Univ, Dept Pathol, Sch Med, Kurume, Fukuoka 8300011, Japan

来源：

MODERN RHEUMATOLOGY | 2013年 / 23卷 / 04期

关键词：

CNS lymphoma; Epstein-Barr virus; Methotrexate; Rheumatoid arthritis; LYMPHOPROLIFERATIVE DISORDERS; DISEASES;

D O I：

10.1007/s10165-012-0717-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with rheumatoid arthritis (RA), especially those treated with methotrexate (MTX), might have an increased risk of lymphoproliferative disorders that are associated with Epstein-Barr virus (EBV). We describe a case of EBV-associated central nervous system (CNS) lymphoma (diffuse large B-cell lymphoma) in a patient with RA on a short course of MTX treatment. The neoplastic cells express the B-cell surface markers (CD20, Pax-5 and CD30), and EBV-encoded RNA was demonstrated by in situ hybridization. The patient's lymphoma did not recur for the 8-year follow-up period after the tumor resection and cessation of MTX. MTX may promote EBV-positive CNS lymphoma in RA patient due to its immunosuppressive properties as well as reactivating latent EBV infection.

引用

页码：832 / 836

页数：5

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