Study on of bioadhesive property of carbomer934 by a gamma camera in vivo

AIM: To study the bioadhesive property of carbomer934 in dog alimentary tract. METHODS: Carbomer934 and ethylcellulose were radiolabelled with technetium-99m; and gastrointestinal emptying rate of materials was measured using the technique of gamma scintigraphy. RESULTS: After oral administration, the maximum intestinal radioactivity of non-bioadhesive granules and bioadhesive granules were observed in the second hour and the sixth hour respectively. Constants of stomach emptying rate of nonadhesive granules, bioadhesive granules I and bioadhesive granules II were 0.774h(-1), 0.265h(-1) and 0.321h(-1) respectively on the base of gastric residual amount. Compared to nonadhesive material (ethylcellulose), the migration rate of adhesive material (carbomer934) was remarkably slower in dog alimentary canal. CONCLUSION: It is concluded that, in the dog, interactions between gastrointestinal mucus layer and adhesive material or nonadhesive material were significantly different. Carbomer934 had stronger in vivo bioadhesive property than ethylcellulose.