The ovarian response to standard gonadotropin stimulation is influenced by AMHRII genotypes

被引：11

作者：

Lazaros, Leandros ^{[1
,2
]}

Fotaki, Anthi ^{[2
]}

Pamporaki, Christina ^{[1
]}

Hatzi, Elissavet ^{[1
]}

Kitsou, Chrysoula ^{[2
]}

Zikopoulos, Athanasios ^{[1
]}

Virgiliou, Christina ^{[3
]}

Kosmas, Ioannis ^{[4
]}

Bouba, Ioanna ^{[2
]}

Stefos, Theodoros ^{[1
]}

Theodoridis, Georgios ^{[3
]}

Georgiou, Ioannis ^{[1
]}

机构：

[1] Ioannina Univ Hosp, Dept Obstet & Gynecol, Med Genet & Assisted Reprod Unit, Ioannina, Greece

[2] Univ Ioannina, Sch Med, Lab Med Genet Human Reprod, Ioannina, Greece

[3] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki, Greece

[4] Ioannina State Gen Hosp G Chatzikosta, Dept Obstet & Gynecol, Ioannina, Greece

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2016年 / 32卷 / 08期

关键词：

AMH receptor; follicles; IVF; oocytes; ovarian stimulation; ANTI-MULLERIAN HORMONE; ASSISTED REPRODUCTION TECHNOLOGY; SINGLE NUCLEOTIDE POLYMORPHISMS; II RECEPTOR POLYMORPHISMS; INHIBITING SUBSTANCE; ANTIMULLERIAN HORMONE; FOLLICLE RECRUITMENT; SIGNALING PATHWAY; MOUSE OVARY; EXPRESSION;

D O I：

10.3109/09513590.2016.1149810

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the current study was to explore whether anti-Mullerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women undergoing medically assisted reproduction. Three hundred in vitro fertilization or intracytoplasmic sperm injection patients constituted the study population, while 300 women with at least one spontaneous pregnancy participated as controls. The follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E-2) and AMH levels were determined at the third day of the menstrual cycle. AMHRII 10A > G (rs11170555), 1749C > T (rs2071558) and -482A > G (rs2002555) polymorphisms were genotyped. The follicle and oocyte numbers, the follicle size and the clinical pregnancies were recorded. Regarding the AMHRII 1749C > T polymorphism, 1749CT women presented with higher total follicle and small follicle numbers compared to 1749CC women (p = 0.04 and p = 0.01, respectively). Whereas, as concerns the -482A > G polymorphism, -482AG women were characterized by higher total follicle and small follicle numbers comparing with -482AA women (p = 0.07 and p = 0.004, respectively). Finally, -482AG women presented with increased FSH levels compared to -482AA women (p < 0.05). However, no associations of AMHRII gene polymorphisms with serum AMH levels or clinical pregnancy rates were observed. AMHRII 1749C > T and -482A > G genetic variants were associated with the ovarian response to standard gonadotropin stimulation, affecting mainly the follicular growth.

引用

页码：641 / 645

页数：5

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