Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

被引：448

作者：

Hanssen, Mark J. W. ^{[1
]}

Hoeks, Joris ^{[1
]}

Brans, Boudewijn ^{[2
]}

van der Lans, Anouk A. J. J. ^{[1
]}

Schaart, Gert ^{[3
]}

van den Driessche, Jose J. ^{[1
]}

Jorgensen, Johanna A. ^{[1
]}

Boekschoten, Mark V. ^{[4
]}

Hesselink, Matthijs K. C. ^{[3
]}

Havekes, Bas ^{[5
]}

Kersten, Sander ^{[4
]}

Mottaghy, Felix M. ^{[2
,6
]}

Lichtenbelt, Wouter D. van Marken ^{[1
]}

Schrauwen, Patrick ^{[1
]}

机构：

[1] Maastricht Univ, Med Ctr, Sch Nutr & Translat Res Metab, Dept Human Biol, Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Dept Nucl Med, Maastricht, Netherlands

[3] Maastricht Univ, Med Ctr, Sch Nutr & Translat Res Metab, Dept Human Movement Sci, Maastricht, Netherlands

[4] Wageningen Univ, Div Human Nutr, Nutr Metab & Genom Grp, NL-6700 AP Wageningen, Netherlands

[5] Maastricht Univ, Med Ctr, Sch Nutr & Translat Res Metab, Dept Internal Med,Div Endocrinol & Metab, Maastricht, Netherlands

[6] Univ Hosp Rhein Westfal Tech Hsch RWTH Aachen, Dept Nucl Med, Aachen, Germany

来源：

NATURE MEDICINE | 2015年 / 21卷 / 08期

关键词：

BROWN ADIPOSE-TISSUE; MITOCHONDRIAL-FUNCTION; ENERGY-EXPENDITURE; GLUCOSE-UPTAKE; FAT; THERMOGENESIS; HOMEOSTASIS;

D O I：

10.1038/nm.3891

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by similar to 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.

引用

页码：863 / 865

页数：3

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