Lithium Ion Recognition with Nanofluidic Diodes through Host-Guest Complexation in Confined Geometries

被引:63
作者
Ali, Mubarak [1 ,2 ]
Ahmed, Ishtiaq [3 ]
Ramirez, Patricio [4 ]
Nasir, Saima [1 ]
Mafe, Salvador [5 ]
Niemeyer, Christof M. [3 ]
Ensinger, Wolfgang [1 ]
机构
[1] Tech Univ Darmstadt, Fachbereich Mat & Geowissensch, Fachgebiet Mat Anal, Alarich Weiss Str 2, D-64287 Darmstadt, Germany
[2] GSI Helmholtzzentrum Schwerionenforsch, Planckstr 1, D-64291 Darmstadt, Germany
[3] KIT, Inst Biol Interfaces IBG 1, Hermann von Helmholtz Pl, D-76344 Eggenstein Leopoldshafen, Germany
[4] Univ Politecn Valencia, Dept Fis Aplicada, E-46022 Valencia, Spain
[5] Univ Valencia, Dept Fis Tierra & Termodinam, E-46100 Burjassot, Spain
关键词
SOLID-STATE NANOPORES; GATED SODIUM-CHANNEL; SINGLE NANOCHANNEL; BIOMOLECULAR RECOGNITION; CURRENT RECTIFICATION; ASYMMETRIC NANOPORES; CONICAL NANOPORES; NOBEL LECTURE; CROWN-ETHERS; CONDUCTION;
D O I
10.1021/acs.analchem.8b00902
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The lithium ion recognition is receiving significant attention because of its application in pharmaceuticals, lubricants and, especially, in energy technology. We present a nanofluidic device for specific lithium ion recognition via host guest complexation in a confined environment. A lithium-selective receptor molecule, the aminoethyl-benzo-12-crown-4 (BC12C4-NH2), is designed and functionalized on single conical nanopores in polyethylene terephthalate (PET) membranes. The native carboxylic acid groups on the pore walls are covalently linked with the crown ether moieties and the process is monitored from the changes in the current voltage (I-V) curves. The B12-crown-4 moieties are known to specifically bind with lithium ions and when the modified pore is exposed to different alkali metal chloride solutions separately, significant changes in the ion current and rectification are only observed for lithium chloride. This fact suggests the generation of positively charged B12C4-Li+ complexes on the pore surface. Furthermore, the nanofluidic diode is able to recognize the lithium ion even in the presence of high concentrations of potassium ions in the external electrolyte solution. Thus, this nanodevice suggests a strategy to miniaturize nanofluidic porous systems for efficient recognition, extraction, and separation of lithium from raw materials.
引用
收藏
页码:6820 / 6826
页数:7
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