L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice

被引：75

作者：

Ayata, C

Ma, JY

Meng, W

Huang, P

Moskowitz, MA

机构：

[1] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,DEPT NEUROSURG & NEUROL,CHARLESTOWN,MA 02129

[2] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,CARDIOVASC RES CTR,CHARLESTOWN,MA 02129

[3] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,DEPT MED,CHARLESTOWN,MA 02129

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1996年 / 16卷 / 04期

关键词：

nitric oxide; cerebral blood flow; mice; knockout; coupling;

D O I：

10.1097/00004647-199607000-00002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Regional cerebral blood flow (rCBF) was studied in type III nitric oxide (NO) synthase (endothelial, eNOS) mutant and wild type mice during mechanical whisker stimulation before and after nitro-L-arginine (L-NA) superfusion using the closed cranial window technique. rCBF increased equally in cortical barrel fields in both strains during stimulation, as measured by laser Doppler-flowmetry, and was inhibited by L-NA superfusion (1 mM) in both groups. Hence, coupling of blood flow and metabolism appears neuronal NOS- (nNOS) but not eNOS-dependent in cortical barrel fields of the mouse.

引用

页码：539 / 541

页数：3

共 10 条

[1] CEREBROVASCULAR RESPONSES UNDER CONTROLLED AND MONITORED PHYSIOLOGICAL CONDITIONS IN THE ANESTHETIZED MOUSE [J].

DALKARA, T ;

IRIKURA, K ;

HUANG, Z ;

PANAHIAN, N ;

MOSKOWITZ, MA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (04) :631-638

[2] ROLE OF NITRIC-OXIDE IN THE COUPLING OF CEREBRAL BLOOD-FLOW TO NEURONAL ACTIVATION IN RATS [J].

DIRNAGL, U ;

LINDAUER, U ;

VILLRINGER, A .

NEUROSCIENCE LETTERS, 1993, 149 (01) :43-46

[3] NITRIC-OXIDE - LINKING SPACE AND TIME IN THE BRAIN [J].

EDELMAN, GM ;

GALLY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11651-11652

[4] HYPERTENSION IN MICE LACKING THE GENE FOR ENDOTHELIAL NITRIC-OXIDE SYNTHASE [J].

HUANG, PL ;

HUANG, ZH ;

MASHIMO, H ;

BLOCH, KD ;

MOSKOWITZ, MA ;

BEVAN, JA ;

FISHMAN, MC .

NATURE, 1995, 377 (6546) :239-242

[5] REGULATION OF THE CEREBRAL MICROCIRCULATION DURING NEURAL ACTIVITY - IS NITRIC-OXIDE THE MISSING LINK [J].

IADECOLA, C .

TRENDS IN NEUROSCIENCES, 1993, 16 (06) :206-214

[6] IMPORTANCE OF NITRIC-OXIDE SYNTHASE INHIBITION TO THE ATTENUATED VASCULAR-RESPONSES INDUCED BY TOPICAL L-NITROARGININE DURING VIBRISSAL STIMULATION [J].

IRIKURA, K ;

MAYNARD, KI ;

MOSKOWITZ, MA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1994, 14 (01) :45-48

[7] EFFECTS OF NG-NITRO-L-ARGININE AND L-ARGININE ON REGIONAL CEREBRAL BLOOD-FLOW IN THE CAT [J].

KOVACH, AGB ;

SZABO, C ;

BENYO, Z ;

CSAKI, C ;

GREENBERG, JH ;

REIVICH, M .

JOURNAL OF PHYSIOLOGY-LONDON, 1992, 449 :183-196

[8] Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression [J].

Ma, JY ;

Ayata, C ;

Huang, PL ;

Fishman, MC ;

Moskowitz, MA .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 270 (03) :H1085-H1090

[9] L-NNA SUPPRESSES CEREBROVASCULAR RESPONSE AND EVOKED-POTENTIALS DURING SOMATOSENSORY STIMULATION IN RATS [J].

NGAI, AC ;

MENO, JR ;

WINN, HR .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 269 (05) :H1803-H1810

[10] COMPETITIVE-INHIBITION OF NITRIC-OXIDE SYNTHASE PREVENTS THE CORTICAL HYPEREMIA ASSOCIATED WITH PERIPHERAL-NERVE STIMULATION [J].

NORTHINGTON, FJ ;

MATHERNE, GP ;

BERNE, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6649-6652

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