Metabolic acidosis and anaemia associated with dorzolamide in a patient with impaired renal function

被引:14
作者
Hoffmanova, Iva [1 ]
Sanchez, Daniel [2 ]
机构
[1] Charles Univ Prague, Fac Med 3, Dept Internal Med 2, Ruska 87, CZ-10000 Prague 10, Czech Republic
[2] Czech Acad Sci, Inst Microbiol, Lab Cellular & Mol Immunol, Vvi, Prague, Czech Republic
关键词
carbonic anhydrase inhibitor; dorzolamide; drug-induced anaemia; drug-induced metabolic acidosis; CARBONIC-ANHYDRASE INHIBITORS; OCULAR HYPERTENSION; CONCISE GUIDE; BRINZOLAMIDE; PHARMACOLOGY; GLAUCOMA; SAFETY; THROMBOCYTOPENIA;
D O I
10.1111/bcp.13499
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Topical carbonic anhydrase inhibitors (CAI), used for treatment of glaucoma, are generally regarded as safe and unconnected with systemic side effects. We report an unusual case of fatigue, metabolic acidosis, and normocytic anaemia associated with ocular administration of the CAI, dorzolamide, in a patient with impaired renal function. In chronic kidney disease, where CAI elimination may be decreased, and patients prone to develop metabolic acidosis, systemic absorption of ocular administered CAI could lead to rare, but potentially serious adverse reaction, that are a consequence of inhibition of extraocular carbonic anhydrase isoenzymes.
引用
收藏
页码:796 / 799
页数:4
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