Physiological and molecular biochemical mechanisms of bile formation

被引：77

作者：

Reshetnyak, Vasiliy Ivanovich ^{[1
]}

机构：

[1] Russian Acad Med Sci, VA Negovsky Sci Res Inst Gen Reanimatol, Moscow 107031, Russia

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 42期

关键词：

Bile acids; Bile phospholipids; Bile micelle structures; Bile salt transporters; SALT EXPORT PUMP; CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE; ALPHA-OST-BETA; HEPATOCYTE NUCLEAR FACTOR-4-ALPHA; CHOLESTATIC LIVER-DISEASE; FARNESOID-X-RECEPTOR; ORGANIC ANION UPTAKE; ACID SYNTHESIS; RAT-LIVER; PLASMA-MEMBRANE;

D O I：

10.3748/wjg.v19.i42.7341

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This review considers the physiological and molecular biochemical mechanisms of bile formation. The composition of bile and structure of a bile canaliculus, biosynthesis and conjugation of bile acids, bile phospholipids, formation of bile micellar structures, and enterohepatic circulation of bile acids are described. In general, the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical membranes. Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes, associated with diseases of the liver and biliary tract. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

引用

页码：7341 / 7360

页数：20

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