Coronin 1 Is Essential for IgM-Mediated Ca2+ Mobilization in B Cells but Dispensable for the Generation of Immune Responses In Vivo

被引：33

作者：

Combaluzier, Benoit ^{[1
]}

Mueller, Philipp ^{[1
]}

Massner, Jan ^{[1
]}

Finke, Daniela ^{[2
]}

Pieters, Jean ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, Basel, Switzerland

[2] Univ Basel, Dept Clin Biol Sci, Basel, Switzerland

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 182卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

BCR CROSS-TALK; T-CELL; ALTERNATE PATHWAY; ANTIGEN RECEPTOR; INDEPENDENT ANTIGENS; CALCIUM MOBILIZATION; ACTIVATION; SURVIVAL; LYN; MYCOBACTERIA;

D O I：

10.4049/jimmunol.0801811

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronin 1 is a leukocyte specific regulator of Ca2+-dependent signaling and is essential for the survival of peripheral T lymphocytes, but its role in B cells is unknown. In this study, we show that coronin 1 is essential for intracellular Ca2+ mobilization and proliferation upon triggering of the BCR. However, the presence of costimulatory signals rendered coronin 1 dispensable for B cell signaling, consistent with the generation of normal immune responses against a variety of Ags in coronin 1-deficient mice. We conclude that coronin 1, while being essential for T cell function and survival, is dispensable for B cell function in vivo. The Journal of Immunology, 2009, 182: 1954-1961.

引用

页码：1954 / 1961

页数：8

共 41 条

[1] Impaired intracellular calcium mobilization and NFATc1 availability in tolerant anti-insulin B cells [J].