Magnetic Resonance Imaging Findings following Intraarticular Infliximab Therapy for Refractory Temporomandibular Joint Arthritis among Children with Juvenile Idiopathic Arthritis

被引：15

作者：

Stoll, Matthew Laurence ^{[1
]}

Vaid, Yoginder Nath ^{[3
]}

Guleria, Saurabh ^{[3
]}

Beukelman, Timothy ^{[1
]}

Waite, Peter Daniel ^{[2
]}

Cron, Randy Quentin ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Pediat, Birmingham, AL USA

[2] Univ Alabama Birmingham, Dept Oral & Maxillofacial Surg, Birmingham, AL USA

[3] Childrens Alabama, Dept Radiol, Birmingham, AL USA

来源：

JOURNAL OF RHEUMATOLOGY | 2015年 / 42卷 / 11期

关键词：

TEMPOROMANDIBULAR JOINT; INFLIXIMAB; INTRAARTICULAR INJECTIONS; JUVENILE IDIOPATHIC ARTHRITIS; MAGNETIC RESONANCE IMAGING; CORTICOSTEROID INJECTIONS; STEROID INJECTION; EFFICACY; SAFETY;

D O I：

10.3899/jrheum.150308

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the involvement of intraarticular (IA) infliximab (IFX) in the management of temporomandibular joint (TMJ) arthritis associated with juvenile idiopathic arthritis (JIA) that is refractory to systemic treatment and IA corticosteroid therapy. Methods. Ours was a retrospective study of children with JIA who received IA IFX into the TMJ. The effectiveness of treatment on the progression of acute and chronic changes was assessed by a quantitative magnetic resonance imaging scoring system. Results. Median acute and chronic scores worsened by 0.25 and 0.75, respectively. In multivariate analysis, worsening acute scores and passage of time predicted worsening of the chronic scores. Conclusion. IA IFX allowed for progression of refractory TMJ arthritis in most but not all children with JIA.

引用

页码：2155 / 2159

页数：5

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