Human embryonic stem cells reveal recurrent genomic instability at 20q11.21

被引：165

作者：

Lefort, Nathalie ^{[1
]}

Feyeux, Maxime ^{[1
]}

Bas, Cecile ^{[2
]}

Feraud, Olivier ^{[3
]}

Bennaceur-Griscelli, Annelise ^{[3
]}

Tachdjian, Gerard ^{[2
]}

Peschanski, Marc ^{[1
]}

Perrier, Anselme L. ^{[1
]}

机构：

[1] Inst Stem Cell Therapy & Explorat Monogen Dis, AFM, INSERM, UEVE,I STEM,UMR 861, F-91030 Evry, France

[2] Univ Paris 11, Hop Antoine Beclere, INSERM, Serv Biol & Genet Reprod,U782, Clamart, France

[3] Univ Paris 11, Hop Paul Brousse, INSERM, U602, Villejuif, France

来源：

NATURE BIOTECHNOLOGY | 2008年 / 26卷 / 12期

关键词：

D O I：

10.1038/nbt.1509

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5-4.6 Mb at 20q11.21, encompassing similar to 23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.

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页码：1364 / 1366

页数：3

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