MicroRNAs and lymphomagenesis: a functional review

被引：68
作者：
Lawrie, Charles H. [1 ,2 ,3 ]
机构：
[1] Biodonostia Res Inst, San Sebastian 20014, Spain
[2] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain
[3] Univ Oxford, Nuffield Dept Clin Lab Sci, Oxford, England
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 160卷 / 05期
关键词：
microRNA; lymph; lymphomagenesis; oncomiR; B-CELL LYMPHOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; NF-KAPPA-B; INDUCED CYTIDINE DEAMINASE; TUMOR-SUPPRESSOR GENES; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; DOWN-REGULATION; IN-VIVO; NEGATIVE REGULATION;
D O I：
10.1111/bjh.12157
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The relatively recent discovery of microRNAs (miRNAs) has exposed an extra layer of gene expression regulation that affects many physiological and pathological processes of biology. Dysregulation of miRNAs is a ubiquitous feature of cancer in general, including lymphomas. The identity of these aberrantly-expressed miRNAs has been thoroughly investigated in all but a few types of lymphomas, however their functional role in lymphomagenesis much less so. This review focuses on those miRNAs that have an experimentally confirmed functional role in the pathogenesis of the most frequent forms of lymphoma. In particular, the MIR15A/16-1 cluster, MIR21, MIR155, MIR17HG (MIR17-92 cluster), MIR34A and MIR125B, which have in vivo animal model evidence for their involvement in lymphomagenesis, are highlighted.
引用
收藏
页码：571 / 581
页数：11
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