Impact of salt form and molecular weight of chitosan on swelling and drug release from chitosan matrix tablets

被引：51

作者：

Huanbutta, Kampanart ^{[1
,2
]}

Cheewatanakornkool, Kamonrak ^{[2
,3
]}

Terada, Katsuhide ^{[4
]}

Nunthanid, Jurairat ^{[2
,3
]}

Sriamornsak, Pornsak ^{[2
,3
]}

机构：

[1] Burapha Univ, Fac Pharmaceut Sci, Chon Buri 20731, Thailand

[2] Silpakorn Univ, Pharmaceut Biopolymer Grp PBiG, Fac Pharm, Nakhon Pathom 73000, Thailand

[3] Silpakorn Univ, Dept Pharmaceut Technol, Fac Pharm, Nakhon Pathom 73000, Thailand

[4] Toho Univ, Fac Pharmaceut Sci, Dept Pharmaceut, Funabashi, Chiba 2748510, Japan

来源：

CARBOHYDRATE POLYMERS | 2013年 / 97卷 / 01期

关键词：

Matrix tablets; Chitosan; Swelling; Erosion; Magnetic resonance imaging; SUSTAINED-RELEASE; MRI METHODS; ACETATE; DELIVERY; BEHAVIOR; EROSION; PH; DISSOLUTION; KINETICS; FILMS;

D O I：

10.1016/j.carbpol.2013.04.073

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Magnetic resonance imaging (MRI) and gravimetric techniques were used to assess swelling and erosion behaviors of hydrophilic matrix tablets made of chitosan. The impact of salt form, molecular weight (MW) and dissolution medium on swelling behavior and drug (theophylline) release was studied. The matrix tablets made of chitosan glycolate (CGY) showed the greatest swelling in both acid and neutral media, compared to chitosan aspartate, chitosan glutamate and chitosan lactate. MRI illustrated that swelling region of CGY in both media was not different in the first 100 min but glassy region (dry core) in 0.1 N HCl was less than in pH 6.8 buffer. The tablets prepared from chitosan with high MW swelled greater than those of low MW. Moreover, CGY can delay drug release in the acid condition due to thick swollen gel and low erosion rate. Therefore, CGY may be suitably applied as sustained drug release polymer or enteric coating material. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：26 / 33

页数：8

共 27 条

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