Immunosuppressant FK506: Focusing on neuroprotective effects following brain and spinal cord injury

被引：25
|
作者：
Saganova, Kamila [1 ]
Galik, Jan [1 ]
Blasko, Juraj [1 ]
Korimova, Andrea [1 ]
Racekova, Eniko [1 ]
Vanicky, Ivo [1 ]
机构：
[1] Slovak Acad Sci, Inst Neurobiol, Ctr Excellence, Kosice 04001, Slovakia
来源：
LIFE SCIENCES | 2012年 / 91卷 / 3-4期
关键词：
Dosing regimen; Combined therapy; Functional outcome; Tissue sparing; FOCAL CEREBRAL-ISCHEMIA; THERAPEUTIC TIME WINDOW; TACROLIMUS FK506; FUNCTIONAL RECOVERY; CYCLOSPORINE-A; IMMUNE-RESPONSES; DAMAGE; RATS; METHYLPREDNISOLONE; FK-506;
D O I：
10.1016/j.lfs.2012.06.022
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The secondary damage that follows central nervous system (CNS) injury is a target for neuroprotective agents aimed at tissue and function sparing. FK506, a clinically used immunosuppressant, acts neuroprotectively in rat models of brain and spinal cord injury and ischemia. Evidence of in vivo experimental studies highlights the neuroprotective role of FK506 by its direct impact on various cell populations within the CNS. The participation of FK506 in modulation of post-traumatic inflammatory processes is a further potential aspect involved in CNS neuroprotection. In this review we provide an overview of the current laboratory research focusing on the multiple effects of FK506 on neuroprotection following CNS injury. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：77 / 82
页数：6
相关论文
共 50 条
  • [21] Effects of immunosuppressant FK-506 on tooth movement
    Santos, R. L.
    de Farias, M. L. F.
    de Mendonca, L. M. C.
    Goncalves, R. T.
    Martins, M. A.
    de Souza, M. M. G.
    ORTHODONTICS & CRANIOFACIAL RESEARCH, 2010, 13 (03) : 153 - 161
  • [22] Olfactory ensheathing glia graft in combination with FK506 administration promote repair after spinal cord injury
    Lopez-Vales, Ruben
    Fores, Joaquim
    Navarro, Xavier
    Verdu, Enrique
    NEUROBIOLOGY OF DISEASE, 2006, 24 (03) : 443 - 454
  • [23] Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture
    Lee, Kyung Hee
    Won, Ran
    Kim, Un Jeng
    Kim, Ga Min
    Chung, Myung-Ae
    Sohn, Jin-Hun
    Lee, Bae Hwan
    NEUROSCIENCE LETTERS, 2010, 474 (03) : 126 - 130
  • [24] Neuroprotective actions of FK506 and cyclosporin A on motor neuron survival following neonatal axotomy
    Iwasaki, Y
    Ichikawa, Y
    Igarashi, O
    Iwamoto, K
    Kinoshitata, M
    Ikeda, K
    NEUROLOGICAL RESEARCH, 2002, 24 (06) : 573 - 576
  • [25] The immunosuppressant drug FK506 prevents Fas-induced apoptosis in human hepatocytes
    Gómez-Lechón, MJ
    Serralta, A
    Donato, MT
    Jiménez, N
    O'Connor, E
    Castell, JV
    Mir, J
    BIOCHEMICAL PHARMACOLOGY, 2004, 68 (12) : 2427 - 2433
  • [26] Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury
    Huang, Ting-Qin
    Song, Jin-Ning
    Zheng, Feng-Wei
    Pang, Hong-Gang
    Zhao, Yong-Lin
    Gu, Hua
    Zhao, Jun-Jie
    MOLECULAR MEDICINE REPORTS, 2017, 15 (05) : 3001 - 3010
  • [27] Differential Effects of FK506 on Structural and Functional Axonal Deficits After Diffuse Brain Injury in the Immature Rat
    DiLeonardi, Ann Mae
    Huh, Jimmy W.
    Raghupathi, Ramesh
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2012, 71 (11): : 959 - 972
  • [28] FK506 Protects Neurons Following Peripheral Nerve Injury Via Immunosuppression
    Kapil Saxena
    Nisha Patro
    Ishan Patro
    Cellular and Molecular Neurobiology, 2007, 27 : 1049 - 1057
  • [29] FK506 protects neurons following peripheral nerve injury via immunosuppression
    Saxena, Kapil
    Patro, Nisha
    Patro, Ishan
    CELLULAR AND MOLECULAR NEUROBIOLOGY, 2007, 27 (08) : 1049 - 1057
  • [30] Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity
    Fields, Jerel A.
    Overk, Cassia
    Adame, Anthony
    Florio, Jazmin
    Mante, Michael
    Pineda, Andrea
    Desplats, Paula
    Rockenstein, Edward
    Achim, Cristian
    Masliah, Eliezer
    JOURNAL OF NEUROINFLAMMATION, 2016, 13
12345