Vancomycin Versus Linezolid in the Treatment of Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia: Implications of the ZEPHyR Trial

被引：9

作者：

Alaniz, Cesar ^{[1
,2
]}

Pogue, Jason M. ^{[3
,4
]}

机构：

[1] Univ Michigan Hosp, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA

[3] Sinai Grace Hosp, Dept Pharm Serv, Detroit, MI USA

[4] Detroit Med Ctr, Detroit, MI USA

来源：

ANNALS OF PHARMACOTHERAPY | 2012年 / 46卷 / 10期

关键词：

linezolid; pneumonia; vancomycin; MINIMUM INHIBITORY CONCENTRATION; 2; DOUBLE-BLIND; BACTEREMIA; MORTALITY;

D O I：

10.1345/aph.1R221

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In 2003, a retrospective trial comparing linezolid versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) showed improved survival in the linezolid group. This led to the ZEPHyR (Linezolid in the Treatment of Subjects with Nosocomial Pneumonia Proven to Be Due to Methicillin-Resistant Staphylococcus aureus) trial comparing linezolid versus vancomycin for MRSA pneumonia, which showed a benefit for linezolid with respect to clinical response but without a survival advantage. Limitations of the study included unbalanced treatment groups at baseline and number of patients excluded to reach the per-protocol group. Results of the ZEPHyR trial do not support routine use of linezolid for the treatment of MRSA pneumonia.

引用

页码：1432 / 1435

页数：4

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