Drug toxicity, HIV progression, or comorbidity of aging: Does tipranavir use increase the risk of intracranial hemorrhage?

被引：21

作者：

Justice, Amy C. ^{[1
,2
]}

Zingmond, David S. ^{[3
]}

Gordon, Kirsha S. ^{[1
,2
]}

Fultz, Shawn L. ^{[1
]}

Goulet, Joseph L. ^{[1
,2
]}

King, Joseph T., Jr. ^{[1
,2
]}

Bravata, Dawn M. ^{[1
,2
]}

Valdez, Hernan ^{[4
]}

Kraft, Michael ^{[5
]}

Mattocks, Kristin M. ^{[1
,2
]}

机构：

[1] VA Connecticut Healthcare Syst, West Haven, CT 06516 USA

[2] Yale Univ, West Haven, CT USA

[3] Univ Calif Los Angeles, New York, NY USA

[4] Pfizer, New York, NY USA

[5] Boehringer Ingelheim KG, D-6507 Ingelheim, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 47卷 / 09期

关键词：

D O I：

10.1086/592302

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The US Food and Drug Administration has issued a warning that tipranavir may be associated with increased risk of intracranial hemorrhage. We studied 2 large cohorts to estimate the background rate of intracranial hemorrhage and compared it with rates reported among persons who had been exposed to tipranavir.

引用

页码：1226 / 1230

页数：5

共 15 条

[1] Monitoring of long-term toxicities of HIV treatments: an international perspective [J].

Bisson, G ;

Gross, R ;

Miller, V ;

Weller, I ;

Walker, A .

AIDS, 2003, 17 (17) :2407-2417

[2] Acquired immunodeficiency syndrome and the risk of stroke [J].

Cole, JW ;

Pinto, AN ;

Hebel, JR ;

Buchholz, DW ;

Earley, CJ ;

Johnson, CJ ;

Macko, RF ;

Price, TR ;

Sloan, MA ;

Stern, BJ ;

Wityk, RJ ;

Wozniak, MA ;

Kittner, SJ .

STROKE, 2004, 35 (01) :51-56

[3] Increased COPD among HIV-positive compared to HIV-negative veterans [J].

Crothers, Kristina ;

Butt, Adeel A. ;

Gibert, Cynthia L. ;

Rodriguez-Barradas, Maria C. ;

Crystal, Stephen ;

Justice, Amy C. .

CHEST, 2006, 130 (05) :1326-1333

[4] STUDYING OUTCOMES AND HOSPITAL UTILIZATION IN THE ELDERLY - THE ADVANTAGES OF A MERGED DATA-BASE FOR MEDICARE AND VETERANS-AFFAIRS-HOSPITALS [J].

FLEMING, C ;

FISHER, ES ;

CHANG, CH ;

BUBOLZ, TA ;

MALENKA, DJ .

MEDICAL CARE, 1992, 30 (05) :377-391

[5] Development and verification of a "virtual" cohort using the national VA health information system [J].

Fultz, Shawn L. ;

Skanderson, Melissa ;

Mole, Larry A. ;

Gandhi, Neel ;

Bryant, Kendall ;

Crystal, Stephen ;

Justice, Amy C. .

MEDICAL CARE, 2006, 44 (08) :S25-S30

[6] Estimating the causal effect of zidovudine on CD4 count with a marginal structural model for repeated measures [J].

Hernán, MA ;

Brumback, BA ;

Robins, JM .

STATISTICS IN MEDICINE, 2002, 21 (12) :1689-1709

[7] Medical disease and alcohol use among veterans with human immunodeficiency infection - A comparison of disease measurement strategies [J].

Justice, Amy C. ;

Lasky, Elaine ;

McGinnis, Kathleen A. ;

Skanderson, Melissa ;

Conigliaro, Joseph ;

Fultz, Shawn L. ;

Crothers, Kristina ;

Rabeneck, Linda ;

Rodriguez-Barradas, Maria ;

Weissman, Sharon B. ;

Bryant, Kendall .

MEDICAL CARE, 2006, 44 (08) :S52-S60

[8] Coding of stroke and stroke risk factors using International Classification of Diseases, revisions 9 and 10 [J].

Kokotailo, RA ;

Hill, MD .

STROKE, 2005, 36 (08) :1776-1781

[9] Changes in the occurrence of and risk factors for hemophilia-associated intracranial hemorrhage [J].

Nuss, R ;

Soucie, JM ;

Evatt, B .

AMERICAN JOURNAL OF HEMATOLOGY, 2001, 68 (01) :37-42

[10] Marginal structural models and causal inference in epidemiology [J].

Robins, JM ;

Hernán, MA ;

Brumback, B .

EPIDEMIOLOGY, 2000, 11 (05) :550-560

← 1 2 →